The effects of silver nanoparticles on behavior, apoptosis and nitro-oxidative stress in offspring Wistar rats

Oana Ofelia Dǎnilǎ; Alexandra Sevastre Berghian; Vlad Dionisie; Dan Gheban; Diana Olteanu; Flaviu Tabaran; Ioana Baldea; Gabriel Katona; Bianca Moldovan; Simona Clichici; Luminita David; Gabriela Adriana Filip

doi:10.2217/nnm-2017-0029

The effects of silver nanoparticles on behavior, apoptosis and nitro-oxidative stress in offspring Wistar rats

Oana Ofelia Dǎnilǎ, Alexandra Sevastre Berghian, Vlad Dionisie, Dan Gheban, Diana Olteanu, Flaviu Tabaran, Ioana Baldea, Gabriel Katona, Bianca Moldovan, Simona Clichici, Luminita David, Gabriela Adriana Filip

Masonic Cancer Center

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Aim: To investigate the comparative effects of prenatal exposure to silver nanoparticles (AgNPs) functionalized with citrate and polyphenols on spatial cognition and also on nitro-oxidative stress and apoptosis in the hippocampus and cerebellum of offsprings. Materials & methods: Pregnant Wistar rats were orally administered substances from day 10 of gestation until day 21. Six weeks postpartum, six male offsprings from each group were used for behavioral evaluation and determination of oxidative stress and apoptosis. Results: Both groups exhibited hyperactivity and anxiety especially after AgNPs-Sambucus nigra L. administration. AgNPs-S. nigra L. group showed increase in induced nitric oxide synthase activity and decrease in superoxide dismutase activity and apoptosis in the hippocampus, while AgNPs-citrate coated administration exerted a moderate toxicity and induced apoptosis. Conclusion: AgNPs functionalized with natural extracts had a lower toxicity than citrate-coated silver particles.

Original language	English (US)
Pages (from-to)	1455-1473
Number of pages	19
Journal	Nanomedicine
Volume	12
Issue number	12
DOIs	https://doi.org/10.2217/nnm-2017-0029
State	Published - Jun 2017

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© 2017 Future Medicine Ltd.

Keywords

apoptosis
cerebellum
hippocampus
nitro-oxidative stress
polyphenols
silver nanoparticles

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title = "The effects of silver nanoparticles on behavior, apoptosis and nitro-oxidative stress in offspring Wistar rats",

abstract = "Aim: To investigate the comparative effects of prenatal exposure to silver nanoparticles (AgNPs) functionalized with citrate and polyphenols on spatial cognition and also on nitro-oxidative stress and apoptosis in the hippocampus and cerebellum of offsprings. Materials & methods: Pregnant Wistar rats were orally administered substances from day 10 of gestation until day 21. Six weeks postpartum, six male offsprings from each group were used for behavioral evaluation and determination of oxidative stress and apoptosis. Results: Both groups exhibited hyperactivity and anxiety especially after AgNPs-Sambucus nigra L. administration. AgNPs-S. nigra L. group showed increase in induced nitric oxide synthase activity and decrease in superoxide dismutase activity and apoptosis in the hippocampus, while AgNPs-citrate coated administration exerted a moderate toxicity and induced apoptosis. Conclusion: AgNPs functionalized with natural extracts had a lower toxicity than citrate-coated silver particles.",

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author = "Dǎnilǎ, {Oana Ofelia} and Berghian, {Alexandra Sevastre} and Vlad Dionisie and Dan Gheban and Diana Olteanu and Flaviu Tabaran and Ioana Baldea and Gabriel Katona and Bianca Moldovan and Simona Clichici and Luminita David and Filip, {Gabriela Adriana}",

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AU - Dǎnilǎ, Oana Ofelia

AU - Berghian, Alexandra Sevastre

AU - Dionisie, Vlad

AU - Gheban, Dan

AU - Olteanu, Diana

AU - Tabaran, Flaviu

AU - Baldea, Ioana

AU - Katona, Gabriel

AU - Moldovan, Bianca

AU - Clichici, Simona

AU - David, Luminita

AU - Filip, Gabriela Adriana

PY - 2017/6

Y1 - 2017/6

N2 - Aim: To investigate the comparative effects of prenatal exposure to silver nanoparticles (AgNPs) functionalized with citrate and polyphenols on spatial cognition and also on nitro-oxidative stress and apoptosis in the hippocampus and cerebellum of offsprings. Materials & methods: Pregnant Wistar rats were orally administered substances from day 10 of gestation until day 21. Six weeks postpartum, six male offsprings from each group were used for behavioral evaluation and determination of oxidative stress and apoptosis. Results: Both groups exhibited hyperactivity and anxiety especially after AgNPs-Sambucus nigra L. administration. AgNPs-S. nigra L. group showed increase in induced nitric oxide synthase activity and decrease in superoxide dismutase activity and apoptosis in the hippocampus, while AgNPs-citrate coated administration exerted a moderate toxicity and induced apoptosis. Conclusion: AgNPs functionalized with natural extracts had a lower toxicity than citrate-coated silver particles.

AB - Aim: To investigate the comparative effects of prenatal exposure to silver nanoparticles (AgNPs) functionalized with citrate and polyphenols on spatial cognition and also on nitro-oxidative stress and apoptosis in the hippocampus and cerebellum of offsprings. Materials & methods: Pregnant Wistar rats were orally administered substances from day 10 of gestation until day 21. Six weeks postpartum, six male offsprings from each group were used for behavioral evaluation and determination of oxidative stress and apoptosis. Results: Both groups exhibited hyperactivity and anxiety especially after AgNPs-Sambucus nigra L. administration. AgNPs-S. nigra L. group showed increase in induced nitric oxide synthase activity and decrease in superoxide dismutase activity and apoptosis in the hippocampus, while AgNPs-citrate coated administration exerted a moderate toxicity and induced apoptosis. Conclusion: AgNPs functionalized with natural extracts had a lower toxicity than citrate-coated silver particles.

KW - apoptosis

KW - cerebellum

KW - hippocampus

KW - nitro-oxidative stress

KW - polyphenols

KW - silver nanoparticles

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The effects of silver nanoparticles on behavior, apoptosis and nitro-oxidative stress in offspring Wistar rats

Abstract

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