The endo-lysosomal system as an NAADP-sensitive acidic Ca2+ store: Role for the two-pore channels

Sandip Patel; Latha Ramakrishnan; Taufiq Rahman; Amro Hamdoun; Jonathan S. Marchant; Colin W. Taylor; Eugen Brailoiu

doi:10.1016/j.ceca.2011.03.011

The endo-lysosomal system as an NAADP-sensitive acidic Ca²⁺ store: Role for the two-pore channels

Sandip Patel, Latha Ramakrishnan, Taufiq Rahman, Amro Hamdoun, Jonathan S. Marchant, Colin W. Taylor, Eugen Brailoiu

Research output: Contribution to journal › Review article › peer-review

59 Scopus citations

Abstract

Accumulating evidence suggests that the endo-lysosomal system provides a substantial store of Ca²⁺ that is tapped by the Ca²⁺-mobilizing messenger, NAADP. In this article, we review evidence that NAADP-mediated Ca²⁺ release from this acidic Ca²⁺ store proceeds through activation of the newly described two-pore channels (TPCs). We discuss recent advances in defining the sub-cellular targeting, topology and biophysics of TPCs. We also discuss physiological roles and the evolution of this ubiquitous ion channel family.

Original language	English (US)
Pages (from-to)	157-167
Number of pages	11
Journal	Cell Calcium
Volume	50
Issue number	2
DOIs	https://doi.org/10.1016/j.ceca.2011.03.011
State	Published - Aug 2011

Bibliographical note

Funding Information:
We thank Dev Churamani, Robert Hooper, Chi Li and Desmond Tobin for useful discussion, and the Bogue foundation (University College London) for facilitating staff exchange. Work in SP's laboratory is funded by the BBSRC . Work in CWT's laboratory is funded by the Wellcome Trust. TR is a Drapers’ Research Fellow at Pembroke College, Cambridge.

Keywords

Acidic calcium stores
Calcium
Endosomes
Lysosomes
NAADP
TPC1
TPC2
TPCN1
TPCN2
Two-pore channels

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title = "The endo-lysosomal system as an NAADP-sensitive acidic Ca2+ store: Role for the two-pore channels",

abstract = "Accumulating evidence suggests that the endo-lysosomal system provides a substantial store of Ca2+ that is tapped by the Ca2+-mobilizing messenger, NAADP. In this article, we review evidence that NAADP-mediated Ca2+ release from this acidic Ca2+ store proceeds through activation of the newly described two-pore channels (TPCs). We discuss recent advances in defining the sub-cellular targeting, topology and biophysics of TPCs. We also discuss physiological roles and the evolution of this ubiquitous ion channel family.",

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note = "Funding Information: We thank Dev Churamani, Robert Hooper, Chi Li and Desmond Tobin for useful discussion, and the Bogue foundation (University College London) for facilitating staff exchange. Work in SP's laboratory is funded by the BBSRC . Work in CWT's laboratory is funded by the Wellcome Trust. TR is a Drapers{\textquoteright} Research Fellow at Pembroke College, Cambridge.",

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AU - Rahman, Taufiq

AU - Hamdoun, Amro

AU - Marchant, Jonathan S.

AU - Taylor, Colin W.

AU - Brailoiu, Eugen

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AB - Accumulating evidence suggests that the endo-lysosomal system provides a substantial store of Ca2+ that is tapped by the Ca2+-mobilizing messenger, NAADP. In this article, we review evidence that NAADP-mediated Ca2+ release from this acidic Ca2+ store proceeds through activation of the newly described two-pore channels (TPCs). We discuss recent advances in defining the sub-cellular targeting, topology and biophysics of TPCs. We also discuss physiological roles and the evolution of this ubiquitous ion channel family.

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