TY - JOUR
T1 - The Irvine, Beatties, and Bresnahan (IBB) forelimb recovery scale
T2 - An assessment of reliability and validity
AU - Irvine, Karen Amanda
AU - Ferguson, Adam R.
AU - Mitchell, Kathleen D.
AU - Beattie, Stephanie B.
AU - Lin, Amity
AU - Stuck, Ellen D.
AU - Huie, J. Russell
AU - Nielson, Jessica L.
AU - Talbott, Jason F.
AU - Inoue, Tomoo
AU - Beattie, Michael S.
AU - Bresnahan, Jacqueline C.
PY - 2014
Y1 - 2014
N2 - The IBB scale is a recently developed forelimb scale for the assessment of fine control of the forelimb and digits after cervical spinal cord injury [SCI; (1)]. The present paper describes the assessment of inter-rater reliability and face, concurrent and construct validity of this scale following SCI. It demonstrates that the IBB is a reliable and valid scale that is sensitive to severity of SCI and to recovery over time. in addition, the IBB correlates with other outcome measures and is highly predictive of biological measures of tissue pathology. Multivariate analysis using principal component analysis (PCA) demonstrates that the IBB is highly predictive of the syndromic outcome after SCI (2), and is among the best predictors of bio-behavioral function, based on strong construct validity. Altogether, the data suggest that the IBB, especially in concert with other measures, is a reliable and valid tool for assessing neurological deficits in fine motor control of the distal forelimb, and represents a powerful addition to multivariate outcome batteries aimed at documenting recovery of function after cervical SCI in rats.
AB - The IBB scale is a recently developed forelimb scale for the assessment of fine control of the forelimb and digits after cervical spinal cord injury [SCI; (1)]. The present paper describes the assessment of inter-rater reliability and face, concurrent and construct validity of this scale following SCI. It demonstrates that the IBB is a reliable and valid scale that is sensitive to severity of SCI and to recovery over time. in addition, the IBB correlates with other outcome measures and is highly predictive of biological measures of tissue pathology. Multivariate analysis using principal component analysis (PCA) demonstrates that the IBB is highly predictive of the syndromic outcome after SCI (2), and is among the best predictors of bio-behavioral function, based on strong construct validity. Altogether, the data suggest that the IBB, especially in concert with other measures, is a reliable and valid tool for assessing neurological deficits in fine motor control of the distal forelimb, and represents a powerful addition to multivariate outcome batteries aimed at documenting recovery of function after cervical SCI in rats.
KW - Forelimb functional task
KW - Recovery of function
KW - Reliability
KW - Spinal cord injury
KW - Validity
UR - http://www.scopus.com/inward/record.url?scp=84904391979&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84904391979&partnerID=8YFLogxK
U2 - 10.3389/fneur.2014.00116
DO - 10.3389/fneur.2014.00116
M3 - Article
AN - SCOPUS:84904391979
SN - 1664-2295
VL - 5 JUL
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 116
ER -