TY - JOUR
T1 - The Marshfield Clinic Personalized Medicine Research Project
T2 - 2008 scientific update and lessons learned in the first 6 years
AU - McCarty, Catherine A.
AU - Peissig, Peggy
AU - Caldwell, Michael D.
AU - Wilke, Russell A.
PY - 2008/9
Y1 - 2008/9
N2 - The Marshfield Clinic Personalized Medicine Research Project is the largest population-based biobank in the USA, with the ability to recontact subjects to obtain additional information to facilitate gene-environment studies. Nearly 20,000 adults have enrolled in the Personalized Medicine Research Project since 2001, after providing active written consent to access their Marshfield Clinic medical records to define phenotype and providing blood samples from which DNA, plasma and serum samples were stored. Numerous studies are underway in the area of pharmacogenetics and genetic epidemiology. In addition to the scientific discoveries being made, much has been learned regarding biobanking and the management of large amounts of data being generated. The purpose of this paper is to share the advice provided by the external Scientific Advisory Board and the scientific lessons learned along the way to build this research infrastructure and facilitate its use.
AB - The Marshfield Clinic Personalized Medicine Research Project is the largest population-based biobank in the USA, with the ability to recontact subjects to obtain additional information to facilitate gene-environment studies. Nearly 20,000 adults have enrolled in the Personalized Medicine Research Project since 2001, after providing active written consent to access their Marshfield Clinic medical records to define phenotype and providing blood samples from which DNA, plasma and serum samples were stored. Numerous studies are underway in the area of pharmacogenetics and genetic epidemiology. In addition to the scientific discoveries being made, much has been learned regarding biobanking and the management of large amounts of data being generated. The purpose of this paper is to share the advice provided by the external Scientific Advisory Board and the scientific lessons learned along the way to build this research infrastructure and facilitate its use.
KW - Biobank
KW - Genetic epidemiology
KW - Methods
KW - Pharmacogenetics
UR - http://www.scopus.com/inward/record.url?scp=56149112638&partnerID=8YFLogxK
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U2 - 10.2217/17410541.5.5.529
DO - 10.2217/17410541.5.5.529
M3 - Article
AN - SCOPUS:56149112638
SN - 1741-0541
VL - 5
SP - 529
EP - 541
JO - Personalized Medicine
JF - Personalized Medicine
IS - 5
ER -