The pulling force of a single DNA molecule condensed by spermidine

Rui Zhang; B. I. Shklovskii

doi:10.1016/j.physa.2004.11.013

The pulling force of a single DNA molecule condensed by spermidine

Rui Zhang, B. I. Shklovskii

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16 Scopus citations

Abstract

In a recent experiment, a single DNA double helix is stretched and relaxed in the presence of spermidine, a short positive polyelectrolyte, and the pulling force is measured as a function of DNA extension. In a certain range of spermidine concentration, a force plateau appears whose value shows maximum as a function of spermidine concentration. We present a quantitative theory of this plateau force based on the theory of reentrant condensation and derive almost parabolic behavior of the plateau force as a function of the logarithm of the spermidine concentration in the range of condensation. Our result is in good agreement with experimental data.

Original language	English (US)
Pages (from-to)	563-570
Number of pages	8
Journal	Physica A: Statistical Mechanics and its Applications
Volume	349
Issue number	3-4
DOIs	https://doi.org/10.1016/j.physa.2004.11.013
State	Published - Apr 15 2005

Bibliographical note

Funding Information:
The authors are grateful to A.Yu. Grosberg, Y. Murayama, Y. Rabin, I. Rouzina, and J. Zhang for useful discussions. This work is supported by NSF No. DMR-9985785 and DMI-0210844.

Keywords

Condensation
DNA
Pulling force
Spermidine

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title = "The pulling force of a single DNA molecule condensed by spermidine",

abstract = "In a recent experiment, a single DNA double helix is stretched and relaxed in the presence of spermidine, a short positive polyelectrolyte, and the pulling force is measured as a function of DNA extension. In a certain range of spermidine concentration, a force plateau appears whose value shows maximum as a function of spermidine concentration. We present a quantitative theory of this plateau force based on the theory of reentrant condensation and derive almost parabolic behavior of the plateau force as a function of the logarithm of the spermidine concentration in the range of condensation. Our result is in good agreement with experimental data.",

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AU - Shklovskii, B. I.

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Y1 - 2005/4/15

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AB - In a recent experiment, a single DNA double helix is stretched and relaxed in the presence of spermidine, a short positive polyelectrolyte, and the pulling force is measured as a function of DNA extension. In a certain range of spermidine concentration, a force plateau appears whose value shows maximum as a function of spermidine concentration. We present a quantitative theory of this plateau force based on the theory of reentrant condensation and derive almost parabolic behavior of the plateau force as a function of the logarithm of the spermidine concentration in the range of condensation. Our result is in good agreement with experimental data.

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The pulling force of a single DNA molecule condensed by spermidine

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