TY - JOUR
T1 - The RISE FOR HEALTH study
T2 - Methods for in-person assessment and biospecimen collection
AU - The Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium
AU - Brubaker, Linda
AU - Barthold, Julia
AU - Fitzgerald, Colleen M.
AU - Kenton, Kimberly
AU - Lewis, Cora E.
AU - Lowder, Jerry
AU - Lukacz, Emily S.
AU - Markland, Alayne
AU - Meister, Melanie
AU - Miller, Janis
AU - Mueller, Elizabeth R.
AU - Rudser, Kyle
AU - Smith, Ariana L.
AU - Newman, Diane K.
N1 - Publisher Copyright:
© 2022 Wiley Periodicals LLC.
PY - 2023/6
Y1 - 2023/6
N2 - Objectives: To describe the methods for the in-person assessment of the RISE FOR HEALTH (RISE) study, a population-based multicenter prospective cohort study designed to identify factors that promote bladder health and/or prevent lower urinary tract symptoms in adult women, conducted by the Prevention of Lower Urinary Tract Symptoms Research Consortium (PLUS). Methods and results: A subset of RISE participants who express interest in the in-person assessment will be screened to ensure eligibility (planned n = 525). Eligible consenting participants are asked to complete 15 physical assessments in addition to height and weight, to assess pelvic floor muscle function, musculoskeletal (MSK) status, and pain, and to provide urogenital microbiome samples. Pelvic floor muscle assessments include presence of prolapse, strength, levator attachment integrity (tear) and myofascial pain. MSK tests evaluate core stability, lumbar spine, pelvic girdle and hip pain and function. Participants are asked to complete the Short Physical Performance Battery to measure balance, lower extremity strength, and functional capacity. All participants are asked to provide a voided urine sample and a vaginal swab for microbiome analyses; a subset of 100 are asked to contribute additional samples for feasibility and validation of a home collection of urinary, vaginal, and fecal biospecimens. Results: Online and in-person training sessions were used to certify research staff at each clinical center before the start of RISE in-person assessments. Standardized protocols and data collection methods are employed uniformly across sites. Conclusions: The RISE in-person assessment is an integral portion of the overall population-based RISE study and represents an innovative approach to assessing factors hypothesized to promote bladder health and/or prevent lower urinary tract symptoms. Data collected from this assessment will be used to prioritize future research questions and prevention strategies and interventions. This description of the assessment methods is intended to provide methodologic transparency and inform other researchers who join efforts to understand and improve bladder health.
AB - Objectives: To describe the methods for the in-person assessment of the RISE FOR HEALTH (RISE) study, a population-based multicenter prospective cohort study designed to identify factors that promote bladder health and/or prevent lower urinary tract symptoms in adult women, conducted by the Prevention of Lower Urinary Tract Symptoms Research Consortium (PLUS). Methods and results: A subset of RISE participants who express interest in the in-person assessment will be screened to ensure eligibility (planned n = 525). Eligible consenting participants are asked to complete 15 physical assessments in addition to height and weight, to assess pelvic floor muscle function, musculoskeletal (MSK) status, and pain, and to provide urogenital microbiome samples. Pelvic floor muscle assessments include presence of prolapse, strength, levator attachment integrity (tear) and myofascial pain. MSK tests evaluate core stability, lumbar spine, pelvic girdle and hip pain and function. Participants are asked to complete the Short Physical Performance Battery to measure balance, lower extremity strength, and functional capacity. All participants are asked to provide a voided urine sample and a vaginal swab for microbiome analyses; a subset of 100 are asked to contribute additional samples for feasibility and validation of a home collection of urinary, vaginal, and fecal biospecimens. Results: Online and in-person training sessions were used to certify research staff at each clinical center before the start of RISE in-person assessments. Standardized protocols and data collection methods are employed uniformly across sites. Conclusions: The RISE in-person assessment is an integral portion of the overall population-based RISE study and represents an innovative approach to assessing factors hypothesized to promote bladder health and/or prevent lower urinary tract symptoms. Data collected from this assessment will be used to prioritize future research questions and prevention strategies and interventions. This description of the assessment methods is intended to provide methodologic transparency and inform other researchers who join efforts to understand and improve bladder health.
KW - bladder
KW - microbiome
KW - musculoskeletal assessment
KW - pelvic floor
KW - women
UR - http://www.scopus.com/inward/record.url?scp=85145313277&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85145313277&partnerID=8YFLogxK
U2 - 10.1002/nau.25108
DO - 10.1002/nau.25108
M3 - Article
C2 - 36573845
AN - SCOPUS:85145313277
SN - 0733-2467
VL - 42
SP - 1011
EP - 1021
JO - Neurourology and Urodynamics
JF - Neurourology and Urodynamics
IS - 5
ER -