TY - JOUR
T1 - The role of motor proteins in photoreceptor protein transport and visual function
AU - Radhakrishnan, Rakesh
AU - Dronamraju, Venkateshwara R.
AU - Leung, Matthias
AU - Gruesen, Andrew
AU - Solanki, Ashish K.
AU - Walterhouse, Stephen
AU - Roehrich, Heidi
AU - Song, Grace
AU - da Costa Monsanto, Rafael
AU - Cureoglu, Sebahattin
AU - Martin, René
AU - Kondkar, Altaf A.
AU - van Kuijk, Frederik J.
AU - Montezuma, Sandra R.
AU - Knöelker, Hans Joachim
AU - Hufnagel, Robert B.
AU - Lobo, Glenn P.
N1 - Publisher Copyright:
© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
PY - 2022
Y1 - 2022
N2 - Background: Rods and cones are photoreceptor neurons in the retina that are required for visual sensation in vertebrates, wherein the perception of vision is initiated when these neurons respond to photons in the light stimuli. The photoreceptor cell is structurally studied as outer segments (OS) and inner segments (IS) where proper protein sorting, localization, and compartmentalization are critical for phototransduction, visual function, and survival. In human retinal diseases, improper protein transport to the OS or mislocalization of proteins to the IS and other cellular compartments could lead to impaired visual responses and photoreceptor cell degeneration that ultimately cause loss of visual function. Results: Therefore, studying and identifying mechanisms involved in facilitating and maintaining proper protein transport in photoreceptor cells would help our understanding of pathologies involving retinal cell degeneration in inherited retinal dystrophies, age-related macular degeneration, and Usher Syndrome. Conclusions: Our mini-review will discuss mechanisms of protein transport within photoreceptors and introduce a novel role for an unconventional motor protein, MYO1C, in actin-based motor transport of the visual chromophore Rhodopsin to the OS, in support of phototransduction and visual function.
AB - Background: Rods and cones are photoreceptor neurons in the retina that are required for visual sensation in vertebrates, wherein the perception of vision is initiated when these neurons respond to photons in the light stimuli. The photoreceptor cell is structurally studied as outer segments (OS) and inner segments (IS) where proper protein sorting, localization, and compartmentalization are critical for phototransduction, visual function, and survival. In human retinal diseases, improper protein transport to the OS or mislocalization of proteins to the IS and other cellular compartments could lead to impaired visual responses and photoreceptor cell degeneration that ultimately cause loss of visual function. Results: Therefore, studying and identifying mechanisms involved in facilitating and maintaining proper protein transport in photoreceptor cells would help our understanding of pathologies involving retinal cell degeneration in inherited retinal dystrophies, age-related macular degeneration, and Usher Syndrome. Conclusions: Our mini-review will discuss mechanisms of protein transport within photoreceptors and introduce a novel role for an unconventional motor protein, MYO1C, in actin-based motor transport of the visual chromophore Rhodopsin to the OS, in support of phototransduction and visual function.
KW - Motor protein
KW - Myosin 1C
KW - Rhodopsin
KW - actin
KW - outer segments
KW - photoreceptor
KW - protein localization
KW - retinal degeneration
KW - trafficking
KW - visual function
UR - http://www.scopus.com/inward/record.url?scp=85130067858&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85130067858&partnerID=8YFLogxK
U2 - 10.1080/13816810.2022.2062391
DO - 10.1080/13816810.2022.2062391
M3 - Review article
C2 - 35470760
AN - SCOPUS:85130067858
SN - 1381-6810
VL - 43
SP - 285
EP - 300
JO - Ophthalmic Genetics
JF - Ophthalmic Genetics
IS - 3
ER -