TY - JOUR
T1 - Tissue-Resident T Cells and Other Resident Leukocytes
AU - Masopust, David
AU - Soerens, Andrew G.
N1 - Publisher Copyright:
© Copyright 2019 by Annual Reviews. All rights reserved.
PY - 2019/4/26
Y1 - 2019/4/26
N2 - Resident memory T (Trm) cells stably occupy tissues and cannot be sampled in superficial venous blood. Trm cells are heterogeneous but collectively constitute the most abundant memory T cell subset. Trm cells form an integral part of the immune sensing network, monitor for local perturbations in homeostasis throughout the body, participate in protection from infection and cancer, and likely promote autoimmunity, allergy, and inflammatory diseases and impede successful transplantation. Thus Trm cells are major candidates for therapeutic manipulation. Here we review CD8+ and CD4+ Trm ontogeny, maintenance, function, and distribution within lymphoid and nonlymphoid tissues and strategies for their study. We briefly discuss other resident leukocyte populations, including innate lymphoid cells, macrophages, natural killer and natural killer T cells, nonclassical T cells, and memory B cells. Lastly, we highlight major gaps in knowledge and propose ways in which a deeper understanding could result in new methods to prevent or treat diverse human diseases.
AB - Resident memory T (Trm) cells stably occupy tissues and cannot be sampled in superficial venous blood. Trm cells are heterogeneous but collectively constitute the most abundant memory T cell subset. Trm cells form an integral part of the immune sensing network, monitor for local perturbations in homeostasis throughout the body, participate in protection from infection and cancer, and likely promote autoimmunity, allergy, and inflammatory diseases and impede successful transplantation. Thus Trm cells are major candidates for therapeutic manipulation. Here we review CD8+ and CD4+ Trm ontogeny, maintenance, function, and distribution within lymphoid and nonlymphoid tissues and strategies for their study. We briefly discuss other resident leukocyte populations, including innate lymphoid cells, macrophages, natural killer and natural killer T cells, nonclassical T cells, and memory B cells. Lastly, we highlight major gaps in knowledge and propose ways in which a deeper understanding could result in new methods to prevent or treat diverse human diseases.
KW - T lymphocytes
KW - immunity
KW - lymphoid cells
KW - memory
KW - residence
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U2 - 10.1146/annurev-immunol-042617-053214
DO - 10.1146/annurev-immunol-042617-053214
M3 - Review article
C2 - 30726153
AN - SCOPUS:85065044573
SN - 0732-0582
VL - 37
SP - 521
EP - 546
JO - Annual Review of Immunology
JF - Annual Review of Immunology
ER -