Topoisomerase II checkpoints: Universal mechanisms that regulate mitosis

Duncan J. Clarke; Amit C. Vas; Catherine A. Andrews; Laura A. Díaz-Martínez; Juan F. Giménez-Abián

doi:10.4161/cc.5.17.3200

Topoisomerase II checkpoints: Universal mechanisms that regulate mitosis

Duncan J. Clarke, Amit C. Vas, Catherine A. Andrews, Laura A. Díaz-Martínez, Juan F. Giménez-Abián

Genetics, Cell Biology and Development (TMED)

Research output: Contribution to journal › Short survey › peer-review

43 Scopus citations

Abstract

Checkpoint controls confer order to the cell cycle and help prevent genome instability. Here we discuss the Topoisomerase II (Decatenation) Checkpoint which functions to regulate mitotic progression so that chromosomes can be efficiently condensed in prophase and can be segregated with high fidelity in anaphase.

Original language	English (US)
Pages (from-to)	1925-1928
Number of pages	4
Journal	Cell Cycle
Volume	5
Issue number	17
DOIs	https://doi.org/10.4161/cc.5.17.3200
State	Published - Sep 1 2006

Bibliographical note

Funding Information:
We thank B Vogelstein for the parental and securin-/- HCT116 cells lines. This work was funded by NIH grant CA099033 (D.J.C.). J.F.G.A was partly supported by MEC-Spain DGI (FYK) and L.A.D.M. by CONACyT.

Keywords

Anaphase
Catenation
Checkpoint
Decatenation
Mad2
Pds1
Top2
Topo II
Topoisomerase II

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title = "Topoisomerase II checkpoints: Universal mechanisms that regulate mitosis",

abstract = "Checkpoint controls confer order to the cell cycle and help prevent genome instability. Here we discuss the Topoisomerase II (Decatenation) Checkpoint which functions to regulate mitotic progression so that chromosomes can be efficiently condensed in prophase and can be segregated with high fidelity in anaphase.",

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AU - Vas, Amit C.

AU - Andrews, Catherine A.

AU - Díaz-Martínez, Laura A.

AU - Giménez-Abián, Juan F.

N1 - Funding Information: We thank B Vogelstein for the parental and securin-/- HCT116 cells lines. This work was funded by NIH grant CA099033 (D.J.C.). J.F.G.A was partly supported by MEC-Spain DGI (FYK) and L.A.D.M. by CONACyT.

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KW - Catenation

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KW - Mad2

KW - Pds1

KW - Top2

KW - Topo II

KW - Topoisomerase II

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Topoisomerase II checkpoints: Universal mechanisms that regulate mitosis

Abstract

Bibliographical note

Keywords

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