Toward patient-specific simulations of cardiac valves: State-of-the-art and future directions

Emiliano Votta; Trung Bao Le; Marco Stevanella; Laura Fusini; Enrico G. Caiani; Alberto Redaelli; Fotis Sotiropoulos

doi:10.1016/j.jbiomech.2012.10.026

Toward patient-specific simulations of cardiac valves: State-of-the-art and future directions

Emiliano Votta, Trung Bao Le, Marco Stevanella, Laura Fusini, Enrico G. Caiani, Alberto Redaelli, Fotis Sotiropoulos

Civil, Environmental, and Geo- Engineering

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Abstract

Recent computational methods enabling patient-specific simulations of native and prosthetic heart valves are reviewed. Emphasis is placed on two critical components of such methods: (1) anatomically realistic finite element models for simulating the structural dynamics of heart valves; and (2) fluid structure interaction methods for simulating the performance of heart valves in a patient-specific beating left ventricle. It is shown that the significant progress achieved in both fronts paves the way toward clinically relevant computational models that can simulate the performance of a range of heart valves, native and prosthetic, in a patient-specific left heart environment. The significant algorithmic and model validation challenges that need to be tackled in the future to realize this goal are also discussed.

Original language	English (US)
Pages (from-to)	217-228
Number of pages	12
Journal	Journal of Biomechanics
Volume	46
Issue number	2
DOIs	https://doi.org/10.1016/j.jbiomech.2012.10.026
State	Published - Jan 18 2013

Bibliographical note

Funding Information:
Reported MV analyses were co-funded by the Italian Ministry of University and Research (PRIN 2007 Program), and supported by Regione Lombardia and CILEA Consortium through a LISA Initiative 2010 grant. Also, these would not have been possible without the invaluable advice of Drs. Mauro Pepi, Gloria Tamborini and Francesco Alamanni from Centro Cardiologico Monzino IRCCS (Milano, Italy). Trung Bao Le and Fotis Sotiropoulos were supported by NIH Grant RO1-HL-07262 and the Minnesota Supercomputing Institute.

Keywords

Finite element model
Fluid structure interaction
Heart valve
Medical imaging
Patient-specific modelling

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AU - Caiani, Enrico G.

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AU - Sotiropoulos, Fotis

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Toward patient-specific simulations of cardiac valves: State-of-the-art and future directions

Abstract

Bibliographical note

Keywords

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