TY - JOUR
T1 - Transmission of Ebola viruses
T2 - What we know and what we do not know
AU - Osterholm, Michael T.
AU - Moore, Kristine A.
AU - Kelley, Nicholas S.
AU - Brosseau, Lisa M.
AU - Wong, Gary
AU - Murphy, Frederick A.
AU - Peters, Clarence J.
AU - LeDuc, James W.
AU - Russell, Phillip K.
AU - Van Herp, Michel
AU - Kapetshi, Jimmy
AU - Muyembe, Jean Jacques T
AU - Ilunga, Benoit Kebela
AU - Strong, James E.
AU - Grolla, Allen
AU - Wolz, Anja
AU - Kargbo, Brima
AU - Kargbo, David K.
AU - Formenty, Pierre
AU - Sanders, David Avram
AU - Kobinger, Gary P.
N1 - Publisher Copyright:
© 2015 Osterholm et al.
PY - 2015/2/19
Y1 - 2015/2/19
N2 - Available evidence demonstrates that direct patient contact and contact with infectious body fluids are the primary modes for Ebola virus transmission, but this is based on a limited number of studies. Key areas requiring further study include (i) the role of aerosol transmission (either via large droplets or small particles in the vicinity of source patients), (ii) the role of environmental contamination and fomite transmission, (iii) the degree to which minimally or mildly ill persons transmit infection, (iv) how long clinically relevant infectiousness persists, (v) the role that “superspreading events” may play in driving transmission dynamics, (vi) whether strain differences or repeated serial passage in outbreak settings can impact virus transmission, and (vii) what role sylvatic or domestic animals could play in outbreak propagation, particularly during major epidemics such as the 2013–2015 West Africa situation. In this review, we address what we know and what we do not know about Ebola virus transmission. We also hypothesize that Ebola viruses have the potential to be respiratory pathogens with primary respiratory spread.
AB - Available evidence demonstrates that direct patient contact and contact with infectious body fluids are the primary modes for Ebola virus transmission, but this is based on a limited number of studies. Key areas requiring further study include (i) the role of aerosol transmission (either via large droplets or small particles in the vicinity of source patients), (ii) the role of environmental contamination and fomite transmission, (iii) the degree to which minimally or mildly ill persons transmit infection, (iv) how long clinically relevant infectiousness persists, (v) the role that “superspreading events” may play in driving transmission dynamics, (vi) whether strain differences or repeated serial passage in outbreak settings can impact virus transmission, and (vii) what role sylvatic or domestic animals could play in outbreak propagation, particularly during major epidemics such as the 2013–2015 West Africa situation. In this review, we address what we know and what we do not know about Ebola virus transmission. We also hypothesize that Ebola viruses have the potential to be respiratory pathogens with primary respiratory spread.
UR - http://www.scopus.com/inward/record.url?scp=84929332445&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929332445&partnerID=8YFLogxK
U2 - 10.1128/mBio.00137-15
DO - 10.1128/mBio.00137-15
M3 - Article
C2 - 25698835
AN - SCOPUS:84929332445
SN - 2161-2129
VL - 6
JO - mBio
JF - mBio
IS - 2
M1 - e00137-15
ER -
