Tri-, tetra- and pentapeptidoylbenzotriazoles: Novel synthetic intermediates

Abdelmotaal Abdelmajeid; Srinivasa R. Tala; M. S. Amine; Alan R. Katritzky

doi:10.1055/s-0030-1260159

Tri-, tetra- and pentapeptidoylbenzotriazoles: Novel synthetic intermediates

Abdelmotaal Abdelmajeid, Srinivasa R. Tala, M. S. Amine, Alan R. Katritzky

Medicinal Chemistry

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9 Scopus citations

Abstract

Conveniently synthesized novel N-(protected α-tri-, tetra- and pentapeptidoyl)benzotriazoles couple in aqueous aceto-nitrile solution at 0C with free amino acids, dipeptides, and tripeptides- to afford N-terminal-protected polypeptides (61-92%) including those containing unprotected OH, SH, and indole NH groups, with no detectable racemization.

Original language	English (US)
Article number	M61111SS
Pages (from-to)	2995-3005
Number of pages	11
Journal	Synthesis
Issue number	18
DOIs	https://doi.org/10.1055/s-0030-1260159
State	Published - 2011

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Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.

Keywords

acylation
amino acids
coupling
medicinal chemistry
peptides

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Tri-, tetra- and pentapeptidoylbenzotriazoles: Novel synthetic intermediates

Abstract

Bibliographical note

Keywords

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