Abstract
The intestinal homeostasis is an orchestrated dynamic equilibrium state composed of the coexistence and interactions among the nutrients, microbial flora, and immune system. The intestinal balance disorder can trigger a series of diseases, such as inflammatory bowel disease (IBD). Many of tryptophan (Trp) metabolites, such as kynurenine and indole, generated under a series of endogenous enzymes or microbial metabolism, have been reported enable to bind and activate the aryl hydrocarbon receptor (AhR), this series of process is termed the Trp-AhR pathway. The activated Trp-AhR pathway can induce the expression of downstream cytokines such as interleukin-22 (IL-22) and interleukin-17 (IL-17), thereby regulating the intestinal homeostasis. This review highlights the advance of Trp-AhR pathway in the regulation of intestinal homeostasis and provides some insights for the clinical strategies that expect to effectively prevent and treat gut diseases via intervening the Trp-AhR pathway.
Original language | English (US) |
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Pages (from-to) | 1760-1768 |
Number of pages | 9 |
Journal | Critical Reviews in Food Science and Nutrition |
Volume | 60 |
Issue number | 10 |
DOIs | |
State | Published - May 30 2020 |
Bibliographical note
Funding Information:Supported by the National Key R&D Program of China (2018YFD0500601 and 2017YFD0500501), the National Natural Science Foundation of China (31829004, 31722054 and 31472101), the College of Animal Science and Technology “Young Talents Program” at China Agricultural University (2017DKA001), the Beijing Nova Programme Interdisciplinary Cooperation Project (xxjc201804), the 111 Project (B16044), and the Developmental Fund for Animal Science by Shenzhen Jinxinnong Feed Co., Ltd.
Funding Information:
Supported by the National Key R&D Program of China (2018YFD0500601 and 2017YFD0500501), the National Natural Science Foundation of China (31829004, 31722054 and 31472101), the College of Animal Science and Technology ?Young Talents Program? at China Agricultural University (2017DKA001), the Beijing Nova Programme Interdisciplinary Cooperation Project (xxjc201804), the 111 Project (B16044), and the Developmental Fund for Animal Science by Shenzhen Jinxinnong Feed Co., Ltd.
Publisher Copyright:
© 2019, © 2019 Taylor & Francis Group, LLC.
Keywords
- Aryl hydrocarbon receptor (AhR)
- immune barrier
- inflammatory bowel disease (IBD)
- intestinal homeostasis
- tryptophan (Trp)
PubMed: MeSH publication types
- Journal Article
- Review