TY - JOUR
T1 - Tweaking biological switches through a better understanding of bistability behavior
AU - Chatterjee, Anushree
AU - Kaznessis, Yiannis N.
AU - Hu, Wei Shou
N1 - Funding Information:
The work is supported partly by a grant from NIH (GM081888) to WSH.
PY - 2008/10
Y1 - 2008/10
N2 - Many biological events are binary. The switch between mutually exclusive OFF to ON state in response to a stimulus is frequently mediated by a control circuit with a positive and/or a negative feedback. Such a system typically exhibits hysteresis with its switching ON and OFF stimulus levels dependent on the current state of the system. The system can be shown to be bistable both experimentally and mathematically. Work to synthesize such switches by combining natural or engineered components has begun to illustrate the potential of such control circuits in many areas of applications.
AB - Many biological events are binary. The switch between mutually exclusive OFF to ON state in response to a stimulus is frequently mediated by a control circuit with a positive and/or a negative feedback. Such a system typically exhibits hysteresis with its switching ON and OFF stimulus levels dependent on the current state of the system. The system can be shown to be bistable both experimentally and mathematically. Work to synthesize such switches by combining natural or engineered components has begun to illustrate the potential of such control circuits in many areas of applications.
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U2 - 10.1016/j.copbio.2008.08.010
DO - 10.1016/j.copbio.2008.08.010
M3 - Review article
C2 - 18804166
AN - SCOPUS:53049099395
SN - 0958-1669
VL - 19
SP - 475
EP - 481
JO - Current opinion in biotechnology
JF - Current opinion in biotechnology
IS - 5
ER -