TY - JOUR
T1 - Ultrafiltration versus usual care for hospitalized patients with heart failure
T2 - The relief for acutely fluid-overloaded patients with decompensated congestive heart failure (RAPID-CHF) trial
AU - Bart, Bradley A.
AU - Boyle, Andrew
AU - Bank, Alan J.
AU - Anand, Inder
AU - Olivari, Maria Teresa
AU - Kraemer, Mark
AU - Mackedanz, Shari
AU - Sobotka, Paul A.
AU - Schollmeyer, Mike
AU - Goldsmith, Steven R.
N1 - Funding Information:
Dr. Sobotka and Mr. Schollmeyer are employees of CHF Solutions Inc.; Dr. Goldsmith has received grant support as director of the Minnesota Heart Failure Consortium for administrative fees and overhead in connection with this trial. Funding for the project was provided by CHF Solutions Inc.
PY - 2005/12/6
Y1 - 2005/12/6
N2 - OBJECTIVES: The purpose of this research was to assess the safety and efficacy of ultrafiltration (UF) in patients admitted with decompensated congestive heart failure (CHF). BACKGROUND: Ultrafiltration for CHF is usually reserved for patients with renal failure or those unresponsive to pharmacologic management. We performed a randomized trial of UF versus usual medical care using a simple UF device that does not require special monitoring or central intravenous access. METHODS: Patients admitted for CHF with evidence of volume overload were randomized to a single, 8 h UF session in addition to usual care or usual care alone. The primary end point was weight loss 24 h after the time of enrollment. RESULTS: Forty patients were enrolled (20 UF, 20 usual care). Ultrafiltration was successful in 18 of the 20 patients in the UF group. Fluid removal after 24 h was 4,650 ml and 2,838 ml in the UF and usual care groups, respectively (p = 0.001). Weight loss after 24 h, the primary end point, was 2.5 kg and 1.86 kg in the UF and usual care groups, respectively (p = 0.240). Patients tolerated UF well. CONCLUSIONS: The early application of UF for patients with CHF was feasible, well-tolerated, and resulted in significant weight loss and fluid removal. A larger trial is underway to determine the relative efficacy of UF versus standard care in acute decompensated heart failure.
AB - OBJECTIVES: The purpose of this research was to assess the safety and efficacy of ultrafiltration (UF) in patients admitted with decompensated congestive heart failure (CHF). BACKGROUND: Ultrafiltration for CHF is usually reserved for patients with renal failure or those unresponsive to pharmacologic management. We performed a randomized trial of UF versus usual medical care using a simple UF device that does not require special monitoring or central intravenous access. METHODS: Patients admitted for CHF with evidence of volume overload were randomized to a single, 8 h UF session in addition to usual care or usual care alone. The primary end point was weight loss 24 h after the time of enrollment. RESULTS: Forty patients were enrolled (20 UF, 20 usual care). Ultrafiltration was successful in 18 of the 20 patients in the UF group. Fluid removal after 24 h was 4,650 ml and 2,838 ml in the UF and usual care groups, respectively (p = 0.001). Weight loss after 24 h, the primary end point, was 2.5 kg and 1.86 kg in the UF and usual care groups, respectively (p = 0.240). Patients tolerated UF well. CONCLUSIONS: The early application of UF for patients with CHF was feasible, well-tolerated, and resulted in significant weight loss and fluid removal. A larger trial is underway to determine the relative efficacy of UF versus standard care in acute decompensated heart failure.
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U2 - 10.1016/j.jacc.2005.05.098
DO - 10.1016/j.jacc.2005.05.098
M3 - Article
C2 - 16325039
AN - SCOPUS:28244434083
SN - 0735-1097
VL - 46
SP - 2043
EP - 2046
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 11
ER -