Abstract
IMPORTANCE: HIV-1 can efficiently transmit from one cell to another but accurate quantification of this mode of transmission is still challenging. Here, we developed an ultrasensitive assay to measure HIV-1 transmission between cells and to evaluate HIV-1 escape from broadly neutralizing antibodies in primary human T cells. This assay will contribute to understanding the fundamental mechanisms of HIV-1 cell-to-cell transmission, allow evaluation of pre-existing or acquired HIV-1 resistance in clinical trials, and can be adapted to study the biology of other retroviruses.
Original language | English (US) |
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Pages (from-to) | e0242823 |
Journal | mBio |
Volume | 15 |
Issue number | 1 |
DOIs | |
State | Published - Jan 16 2024 |
Keywords
- broadly neutralizing antibodies
- cell-cell transmission
- HIV-1
PubMed: MeSH publication types
- Journal Article