TY - JOUR
T1 - Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models
AU - Homberg, Judith R.
AU - Kyzar, Evan J.
AU - Nguyen, Michael
AU - Norton, William H.
AU - Pittman, Julian
AU - Poudel, Manoj K.
AU - Gaikwad, Siddharth
AU - Nakamura, Shun
AU - Koshiba, Mamiko
AU - Yamanouchi, Hideo
AU - Scattoni, Maria Luisa
AU - Ullman, Jeremy F P
AU - Diamond, David M.
AU - Kaluyeva, Aleksandra A.
AU - Parker, Matthew O.
AU - Klimenko, Victor M.
AU - Apryatin, Sergey A.
AU - Brown, Richard E.
AU - Song, Cai
AU - Gainetdinov, Raul R.
AU - Gottesman, Irving I.
AU - Kalueff, Allan V.
N1 - Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize how preclinical models play a key role in gaining translational and mechanistic insights into NDDs and their therapy.
AB - Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize how preclinical models play a key role in gaining translational and mechanistic insights into NDDs and their therapy.
KW - Experimental model
KW - Model organism
KW - Neurodevelopmental disorder
KW - Preclinical study
KW - Translational research
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U2 - 10.1016/j.neubiorev.2016.03.013
DO - 10.1016/j.neubiorev.2016.03.013
M3 - Review article
C2 - 27048961
AN - SCOPUS:84963894206
SN - 0149-7634
VL - 65
SP - 292
EP - 312
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -