Unfolding the role of stress response signaling in endocrine resistant breast cancers

Robert Clarke; Katherine L. Cook

doi:10.3389/fonc.2015.00140

Unfolding the role of stress response signaling in endocrine resistant breast cancers

Robert Clarke, Katherine L. Cook

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

The unfolded protein response (UPR) is an ancient stress response that enables a cell to manage the energetic stress that accompanies protein folding. There has been a significant recent increase in our understanding of the UPR, how it integrates physiological processes within cells, and how this integration can affect cancer cells and cell fate decisions. Recent publications have highlighted the role of UPR signaling components on mediating various cell survival pathways, cellular metabolism and bioenergenics, and autophagy. We address the role of UPR on mediating endocrine therapy resistance and estrogen receptor-positive breast cancer cell survival.

Original language	English (US)
Article number	140
Journal	Frontiers in Oncology
Volume	5
Issue number	JUN
DOIs	https://doi.org/10.3389/fonc.2015.00140
State	Published - 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 Clarke and Cook.

Keywords

Antiestrogen resistant breast cancer
Estrogen receptor-α
Glucose regulated protein 78
ICI 182,780
Tamoxifen
Unfolded protein response
X-box binding protein 1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Unfolding the role of stress response signaling in endocrine resistant breast cancers",

abstract = "The unfolded protein response (UPR) is an ancient stress response that enables a cell to manage the energetic stress that accompanies protein folding. There has been a significant recent increase in our understanding of the UPR, how it integrates physiological processes within cells, and how this integration can affect cancer cells and cell fate decisions. Recent publications have highlighted the role of UPR signaling components on mediating various cell survival pathways, cellular metabolism and bioenergenics, and autophagy. We address the role of UPR on mediating endocrine therapy resistance and estrogen receptor-positive breast cancer cell survival.",

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AB - The unfolded protein response (UPR) is an ancient stress response that enables a cell to manage the energetic stress that accompanies protein folding. There has been a significant recent increase in our understanding of the UPR, how it integrates physiological processes within cells, and how this integration can affect cancer cells and cell fate decisions. Recent publications have highlighted the role of UPR signaling components on mediating various cell survival pathways, cellular metabolism and bioenergenics, and autophagy. We address the role of UPR on mediating endocrine therapy resistance and estrogen receptor-positive breast cancer cell survival.

KW - Antiestrogen resistant breast cancer

KW - Estrogen receptor-α

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KW - ICI 182,780

KW - Tamoxifen

KW - Unfolded protein response

KW - X-box binding protein 1

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ER -

Unfolding the role of stress response signaling in endocrine resistant breast cancers

Abstract

Bibliographical note

Keywords

UN SDGs

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