Unique profile of adenoid cystic carcinoma: A triple negative breast tumor with paradoxical features, a case report and review of literature

Dana Jaggessarsingh; Talia M. Muram-Zborovski; Lynne Bemis; William A. Robinson; Christina Finlayson; Meenakshi Singh

doi:10.1309/LMZAUXKP4JDZ5Z9W

Unique profile of adenoid cystic carcinoma: A triple negative breast tumor with paradoxical features, a case report and review of literature

Dana Jaggessarsingh, Talia M. Muram-Zborovski, Lynne Bemis, William A. Robinson, Christina Finlayson, Meenakshi Singh

Biomedical Sciences

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Abstract

Adenoid cystic carcinomas (ACC) of the breast are uncommon tumors that are not well characterized and have seemingly paradoxical features. We report the case of a deceptively well circumscribed adenoid cystic carcinoma with multiple additional foci of invasive tumor. Immunohistochemical studies revealed an estrogen receptor (ER), progesterone receptor (PR), Human epidermal growth factor Receptor 2 (HER2/neu) negative tumor (triple negative tumor) with immunoreactivity for p63 and, CD 117 (c-kit). p53 was not over expressed. Gene studies did not reveal mutations in the commonly mutated exons of the TP53 and KIT genes. The unique and paradoxical features of this tumor are presented along with a review of the literature.

Original language	English (US)
Pages (from-to)	713-717
Number of pages	5
Journal	Laboratory medicine
Volume	41
Issue number	12
DOIs	https://doi.org/10.1309/LMZAUXKP4JDZ5Z9W
State	Published - Dec 2010

Keywords

Adenoid cystic carcinoma
Immunohistochemistry
Molecular profile
Triple negative breast carcinoma

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title = "Unique profile of adenoid cystic carcinoma: A triple negative breast tumor with paradoxical features, a case report and review of literature",

abstract = "Adenoid cystic carcinomas (ACC) of the breast are uncommon tumors that are not well characterized and have seemingly paradoxical features. We report the case of a deceptively well circumscribed adenoid cystic carcinoma with multiple additional foci of invasive tumor. Immunohistochemical studies revealed an estrogen receptor (ER), progesterone receptor (PR), Human epidermal growth factor Receptor 2 (HER2/neu) negative tumor (triple negative tumor) with immunoreactivity for p63 and, CD 117 (c-kit). p53 was not over expressed. Gene studies did not reveal mutations in the commonly mutated exons of the TP53 and KIT genes. The unique and paradoxical features of this tumor are presented along with a review of the literature.",

keywords = "Adenoid cystic carcinoma, Immunohistochemistry, Molecular profile, Triple negative breast carcinoma",

author = "Dana Jaggessarsingh and Muram-Zborovski, {Talia M.} and Lynne Bemis and Robinson, {William A.} and Christina Finlayson and Meenakshi Singh",

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language = "English (US)",

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AU - Jaggessarsingh, Dana

AU - Muram-Zborovski, Talia M.

AU - Bemis, Lynne

AU - Robinson, William A.

AU - Finlayson, Christina

AU - Singh, Meenakshi

PY - 2010/12

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N2 - Adenoid cystic carcinomas (ACC) of the breast are uncommon tumors that are not well characterized and have seemingly paradoxical features. We report the case of a deceptively well circumscribed adenoid cystic carcinoma with multiple additional foci of invasive tumor. Immunohistochemical studies revealed an estrogen receptor (ER), progesterone receptor (PR), Human epidermal growth factor Receptor 2 (HER2/neu) negative tumor (triple negative tumor) with immunoreactivity for p63 and, CD 117 (c-kit). p53 was not over expressed. Gene studies did not reveal mutations in the commonly mutated exons of the TP53 and KIT genes. The unique and paradoxical features of this tumor are presented along with a review of the literature.

AB - Adenoid cystic carcinomas (ACC) of the breast are uncommon tumors that are not well characterized and have seemingly paradoxical features. We report the case of a deceptively well circumscribed adenoid cystic carcinoma with multiple additional foci of invasive tumor. Immunohistochemical studies revealed an estrogen receptor (ER), progesterone receptor (PR), Human epidermal growth factor Receptor 2 (HER2/neu) negative tumor (triple negative tumor) with immunoreactivity for p63 and, CD 117 (c-kit). p53 was not over expressed. Gene studies did not reveal mutations in the commonly mutated exons of the TP53 and KIT genes. The unique and paradoxical features of this tumor are presented along with a review of the literature.

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KW - Molecular profile

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Unique profile of adenoid cystic carcinoma: A triple negative breast tumor with paradoxical features, a case report and review of literature

Abstract

Keywords

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