TY - JOUR
T1 - Unravelling the sex-specific diversity and functions of adrenal gland macrophages
AU - Dolfi, Bastien
AU - Gallerand, Alexandre
AU - Firulyova, Maria M.
AU - Xu, Yingzheng
AU - Merlin, Johanna
AU - Dumont, Adélie
AU - Castiglione, Alexia
AU - Vaillant, Nathalie
AU - Quemener, Sandrine
AU - Gerke, Heidi
AU - Stunault, Marion I.
AU - Schrank, Patricia R.
AU - Kim, Seung Hyeon
AU - Zhu, Alisha
AU - Ding, Jie
AU - Gilleron, Jerome
AU - Magnone, Virginie
AU - Barbry, Pascal
AU - Dombrowicz, David
AU - Duranton, Christophe
AU - Wakkach, Abdelilah
AU - Blin-Wakkach, Claudine
AU - Becher, Burkhard
AU - Pagnotta, Sophie
AU - Argüello, Rafael J.
AU - Rantakari, Pia
AU - Chakarov, Svetoslav
AU - Ginhoux, Florent
AU - Zaitsev, Konstantin
AU - Kim, Ki Wook
AU - Yvan-Charvet, Laurent
AU - Guinamard, Rodolphe R.
AU - Williams, Jesse W.
AU - Ivanov, Stoyan
N1 - Publisher Copyright:
© 2022 The Author(s)
PY - 2022/6/14
Y1 - 2022/6/14
N2 - Despite the ubiquitous function of macrophages across the body, the diversity, origin, and function of adrenal gland macrophages remain largely unknown. We define the heterogeneity of adrenal gland immune cells using single-cell RNA sequencing and use genetic models to explore the developmental mechanisms yielding macrophage diversity. We define populations of monocyte-derived and embryonically seeded adrenal gland macrophages and identify a female-specific subset with low major histocompatibility complex (MHC) class II expression. In adulthood, monocyte recruitment dominates adrenal gland macrophage maintenance in female mice. Adrenal gland macrophage sub-tissular distribution follows a sex-dimorphic pattern, with MHC class IIlow macrophages located at the cortico-medullary junction. Macrophage sex dimorphism depends on the presence of the cortical X-zone. Adrenal gland macrophage depletion results in altered tissue homeostasis, modulated lipid metabolism, and decreased local aldosterone production during stress exposure. Overall, these data reveal the heterogeneity of adrenal gland macrophages and point toward sex-restricted distribution and functions of these cells.
AB - Despite the ubiquitous function of macrophages across the body, the diversity, origin, and function of adrenal gland macrophages remain largely unknown. We define the heterogeneity of adrenal gland immune cells using single-cell RNA sequencing and use genetic models to explore the developmental mechanisms yielding macrophage diversity. We define populations of monocyte-derived and embryonically seeded adrenal gland macrophages and identify a female-specific subset with low major histocompatibility complex (MHC) class II expression. In adulthood, monocyte recruitment dominates adrenal gland macrophage maintenance in female mice. Adrenal gland macrophage sub-tissular distribution follows a sex-dimorphic pattern, with MHC class IIlow macrophages located at the cortico-medullary junction. Macrophage sex dimorphism depends on the presence of the cortical X-zone. Adrenal gland macrophage depletion results in altered tissue homeostasis, modulated lipid metabolism, and decreased local aldosterone production during stress exposure. Overall, these data reveal the heterogeneity of adrenal gland macrophages and point toward sex-restricted distribution and functions of these cells.
KW - CP: Immunology
KW - adrenal gland
KW - macrophage
KW - monocyte
KW - sex dimorphism
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UR - http://www.scopus.com/inward/citedby.url?scp=85131969315&partnerID=8YFLogxK
U2 - 10.1016/j.celrep.2022.110949
DO - 10.1016/j.celrep.2022.110949
M3 - Article
C2 - 35705045
AN - SCOPUS:85131969315
SN - 2211-1247
VL - 39
JO - Cell reports
JF - Cell reports
IS - 11
M1 - 110949
ER -