Using a web platform for equitable distribution of COVID-19 monoclonal antibodies: a case study in resource allocation

Jonathon P. Leider, Sarah Lim, Debra DeBruin, Alexandra T. Waterman, Barbara Smith, Umesh Ghimire, Haley Huhtala, Zachary Zirnhelt, Ruth Lynfield, John L Hick

Research output: Contribution to journalArticlepeer-review

Abstract

While medical countermeasures in COVID-19 have largely focused on vaccinations, monoclonal antibodies (mAbs) were early outpatient treatment options for COVID-positive patients. In Minnesota, a centralized access platform was developed to offer access to mAbs that linked over 31,000 patients to care during its operation. The website allowed patients, their representative, or providers to screen the patient for mAbs against Emergency Use Authorization (EUA) criteria and connect them with a treatment site if provisionally eligible. A validated clinical risk scoring system was used to prioritize patients during times of scarcity. Both an ethics and a clinical subject matter expert group advised the Minnesota Department of Health on equitable approaches to distribution across a range of situations as the pandemic evolved. This case study outlines the implementation of this online platform and clinical outcomes of its users. We assess the impact of referral for mAbs on hospitalizations and death during a period of scarcity, finding in particular that vaccination conferred a substantially larger protection against hospitalization than a referral for mAbs, but among unvaccinated users that did not get a referral, chances of hospitalization increased by 4.1 percentage points.

Original languageEnglish (US)
Article number1226935
JournalFrontiers in Public Health
Volume11
DOIs
StatePublished - 2023

Bibliographical note

Publisher Copyright:
Copyright © 2023 Leider, Lim, DeBruin, Waterman, Smith, Ghimire, Huhtala, Zirnhelt, Lynfield and Hick.

Keywords

  • case study
  • COVID-19 response
  • crisis standards of care
  • equitable allocation of resources
  • monoclonal antibody
  • public health preparedness
  • scarce resource allocation

PubMed: MeSH publication types

  • Journal Article

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