TY - JOUR
T1 - Using a web platform for equitable distribution of COVID-19 monoclonal antibodies
T2 - a case study in resource allocation
AU - Leider, Jonathon P.
AU - Lim, Sarah
AU - DeBruin, Debra
AU - Waterman, Alexandra T.
AU - Smith, Barbara
AU - Ghimire, Umesh
AU - Huhtala, Haley
AU - Zirnhelt, Zachary
AU - Lynfield, Ruth
AU - Hick, John L
N1 - Publisher Copyright:
Copyright © 2023 Leider, Lim, DeBruin, Waterman, Smith, Ghimire, Huhtala, Zirnhelt, Lynfield and Hick.
PY - 2023
Y1 - 2023
N2 - While medical countermeasures in COVID-19 have largely focused on vaccinations, monoclonal antibodies (mAbs) were early outpatient treatment options for COVID-positive patients. In Minnesota, a centralized access platform was developed to offer access to mAbs that linked over 31,000 patients to care during its operation. The website allowed patients, their representative, or providers to screen the patient for mAbs against Emergency Use Authorization (EUA) criteria and connect them with a treatment site if provisionally eligible. A validated clinical risk scoring system was used to prioritize patients during times of scarcity. Both an ethics and a clinical subject matter expert group advised the Minnesota Department of Health on equitable approaches to distribution across a range of situations as the pandemic evolved. This case study outlines the implementation of this online platform and clinical outcomes of its users. We assess the impact of referral for mAbs on hospitalizations and death during a period of scarcity, finding in particular that vaccination conferred a substantially larger protection against hospitalization than a referral for mAbs, but among unvaccinated users that did not get a referral, chances of hospitalization increased by 4.1 percentage points.
AB - While medical countermeasures in COVID-19 have largely focused on vaccinations, monoclonal antibodies (mAbs) were early outpatient treatment options for COVID-positive patients. In Minnesota, a centralized access platform was developed to offer access to mAbs that linked over 31,000 patients to care during its operation. The website allowed patients, their representative, or providers to screen the patient for mAbs against Emergency Use Authorization (EUA) criteria and connect them with a treatment site if provisionally eligible. A validated clinical risk scoring system was used to prioritize patients during times of scarcity. Both an ethics and a clinical subject matter expert group advised the Minnesota Department of Health on equitable approaches to distribution across a range of situations as the pandemic evolved. This case study outlines the implementation of this online platform and clinical outcomes of its users. We assess the impact of referral for mAbs on hospitalizations and death during a period of scarcity, finding in particular that vaccination conferred a substantially larger protection against hospitalization than a referral for mAbs, but among unvaccinated users that did not get a referral, chances of hospitalization increased by 4.1 percentage points.
KW - case study
KW - COVID-19 response
KW - crisis standards of care
KW - equitable allocation of resources
KW - monoclonal antibody
KW - public health preparedness
KW - scarce resource allocation
UR - http://www.scopus.com/inward/record.url?scp=85179732267&partnerID=8YFLogxK
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U2 - 10.3389/fpubh.2023.1226935
DO - 10.3389/fpubh.2023.1226935
M3 - Article
C2 - 38106886
AN - SCOPUS:85179732267
SN - 2296-2565
VL - 11
JO - Frontiers in Public Health
JF - Frontiers in Public Health
M1 - 1226935
ER -