Vascular health across young adulthood and midlife cerebral autoregulation, gait, and cognition

Simin Mahinrad; Meghana Shownkeen; Sanaz Sedaghat; Kristine Yaffe; Jeffrey M. Hausdorff; Donald M. Lloyd-Jones; Philip B. Gorelick; Farzaneh A. Sorond

doi:10.1002/alz.12246

Vascular health across young adulthood and midlife cerebral autoregulation, gait, and cognition

Simin Mahinrad, Meghana Shownkeen, Sanaz Sedaghat, Kristine Yaffe, Jeffrey M. Hausdorff, Donald M. Lloyd-Jones, Philip B. Gorelick, Farzaneh A. Sorond

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Introduction: To test the association of vascular health (VH) across young adulthood with midlife dynamic cerebral autoregulation (dCA), gait, and cognition; and to test whether dCA is a modifying factor. Methods: We studied 196 participants from the Coronary Artery Risk Development in Young Adults cohort who were followed over 30 years. VH was assessed at each visit according to American Heart Association recommendations. At year 30, dCA was measured using transcranial Doppler ultrasound and several gait and cognitive domains were assessed. Results: Worse VH from baseline through year 7, but not at year 30, was associated with less efficient dCA (all P <.05). Worse VH at all visits was associated with slower gait speed, and at year 7 with worse executive and global cognition (all P <.05). The association of baseline VH and midlife gait, but not cognition, was moderated by dCA (interaction P <.05). Conclusions: VH as early as young adulthood may influence midlife brain health, and dCA may modify this relationship.

Original language	English (US)
Pages (from-to)	745-754
Number of pages	10
Journal	Alzheimer's and Dementia
Volume	17
Issue number	5
DOIs	https://doi.org/10.1002/alz.12246
State	Published - May 2021
Externally published	Yes

Bibliographical note

Funding Information:
We would like to thank Chaney R. Garner, BA, from the Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, for technical assistance and data collection. The Cerebral Small Vessel in Motor and Cognitive Decline study is supported by the National Institutes of Health (NIH, R01NS085002). The Coronary Artery Risk Development in Young Adults Study (CARDIA) is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham (HHSN268201800005I & HHSN268201800007I), Northwestern University (HHSN268201800003I), University of Minnesota (HHSN268201800006I), and Kaiser Foundation Research Institute (HHSN268201800004I). This article has been reviewed by CARDIA for scientific content.

Publisher Copyright:
© 2020 the Alzheimer's Association

Keywords

cerebral autoregulation
cognitive function
gait
midlife
vascular risk factors

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@article{610a64846bc54cb18ceb93734b845ba2,

title = "Vascular health across young adulthood and midlife cerebral autoregulation, gait, and cognition",

abstract = "Introduction: To test the association of vascular health (VH) across young adulthood with midlife dynamic cerebral autoregulation (dCA), gait, and cognition; and to test whether dCA is a modifying factor. Methods: We studied 196 participants from the Coronary Artery Risk Development in Young Adults cohort who were followed over 30 years. VH was assessed at each visit according to American Heart Association recommendations. At year 30, dCA was measured using transcranial Doppler ultrasound and several gait and cognitive domains were assessed. Results: Worse VH from baseline through year 7, but not at year 30, was associated with less efficient dCA (all P <.05). Worse VH at all visits was associated with slower gait speed, and at year 7 with worse executive and global cognition (all P <.05). The association of baseline VH and midlife gait, but not cognition, was moderated by dCA (interaction P <.05). Conclusions: VH as early as young adulthood may influence midlife brain health, and dCA may modify this relationship.",

keywords = "cerebral autoregulation, cognitive function, gait, midlife, vascular risk factors",

author = "Simin Mahinrad and Meghana Shownkeen and Sanaz Sedaghat and Kristine Yaffe and Hausdorff, {Jeffrey M.} and Lloyd-Jones, {Donald M.} and Gorelick, {Philip B.} and Sorond, {Farzaneh A.}",

note = "Funding Information: We would like to thank Chaney R. Garner, BA, from the Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, for technical assistance and data collection. The Cerebral Small Vessel in Motor and Cognitive Decline study is supported by the National Institutes of Health (NIH, R01NS085002). The Coronary Artery Risk Development in Young Adults Study (CARDIA) is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham (HHSN268201800005I & HHSN268201800007I), Northwestern University (HHSN268201800003I), University of Minnesota (HHSN268201800006I), and Kaiser Foundation Research Institute (HHSN268201800004I). This article has been reviewed by CARDIA for scientific content. Publisher Copyright: {\textcopyright} 2020 the Alzheimer's Association",

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month = may,

doi = "10.1002/alz.12246",

language = "English (US)",

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AU - Mahinrad, Simin

AU - Shownkeen, Meghana

AU - Sedaghat, Sanaz

AU - Yaffe, Kristine

AU - Hausdorff, Jeffrey M.

AU - Lloyd-Jones, Donald M.

AU - Gorelick, Philip B.

AU - Sorond, Farzaneh A.

N1 - Funding Information: We would like to thank Chaney R. Garner, BA, from the Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, for technical assistance and data collection. The Cerebral Small Vessel in Motor and Cognitive Decline study is supported by the National Institutes of Health (NIH, R01NS085002). The Coronary Artery Risk Development in Young Adults Study (CARDIA) is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham (HHSN268201800005I & HHSN268201800007I), Northwestern University (HHSN268201800003I), University of Minnesota (HHSN268201800006I), and Kaiser Foundation Research Institute (HHSN268201800004I). This article has been reviewed by CARDIA for scientific content. Publisher Copyright: © 2020 the Alzheimer's Association

PY - 2021/5

Y1 - 2021/5

N2 - Introduction: To test the association of vascular health (VH) across young adulthood with midlife dynamic cerebral autoregulation (dCA), gait, and cognition; and to test whether dCA is a modifying factor. Methods: We studied 196 participants from the Coronary Artery Risk Development in Young Adults cohort who were followed over 30 years. VH was assessed at each visit according to American Heart Association recommendations. At year 30, dCA was measured using transcranial Doppler ultrasound and several gait and cognitive domains were assessed. Results: Worse VH from baseline through year 7, but not at year 30, was associated with less efficient dCA (all P <.05). Worse VH at all visits was associated with slower gait speed, and at year 7 with worse executive and global cognition (all P <.05). The association of baseline VH and midlife gait, but not cognition, was moderated by dCA (interaction P <.05). Conclusions: VH as early as young adulthood may influence midlife brain health, and dCA may modify this relationship.

AB - Introduction: To test the association of vascular health (VH) across young adulthood with midlife dynamic cerebral autoregulation (dCA), gait, and cognition; and to test whether dCA is a modifying factor. Methods: We studied 196 participants from the Coronary Artery Risk Development in Young Adults cohort who were followed over 30 years. VH was assessed at each visit according to American Heart Association recommendations. At year 30, dCA was measured using transcranial Doppler ultrasound and several gait and cognitive domains were assessed. Results: Worse VH from baseline through year 7, but not at year 30, was associated with less efficient dCA (all P <.05). Worse VH at all visits was associated with slower gait speed, and at year 7 with worse executive and global cognition (all P <.05). The association of baseline VH and midlife gait, but not cognition, was moderated by dCA (interaction P <.05). Conclusions: VH as early as young adulthood may influence midlife brain health, and dCA may modify this relationship.

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JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

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Vascular health across young adulthood and midlife cerebral autoregulation, gait, and cognition

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