Watch and wait after neoadjuvant treatment in rectal cancer: Comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & Wait Database (IWWD)

Sofieke J.D. Temmink; Koen C.M.J. Peeters; Renu R. Bahadoer; Elma Meershoek Klein Kranenbarg; Annet G.H. Roodvoets; Jarno Melenhorst; Jacobus W.A. Burger; Albert Wolthuis; Andrew G. Renehan; Nuno L. Figueiredo; Oriol Pares; Anna Martling; Rodrigo O. Perez; Geerard L. Beets; Cornelis J.H. Van De Velde; Per J. Nilsson; M. Aghili; A. Keshvari; M. K. Nouritaromlou; M. Ahlberg; S. Kordnejad; A. Aleinikov; A. Dulskas; O. Asoǧlu; H. Tokmak; R. G. Barroca; A. F. Caiado; I. A.L. Rosa; S. O. Breukink; M. F. Coraglio; S. Iseas; B. Creaven; D. C. Winter; A. Zaborowski; C. Cunningham; E. Gregory; P. A. Custers; B. M. Geubels; L. Debrun; A. D'Hoore; G. Dimofte; K. Fechner; K. Matzel; L. Fernandez; A. I. Herrando; P. Vieira; W. B. Gaertner; R. D. Madoff; J. P. Gerard; F. Jacquinot; R. Schiappa; S. Gollins; M. Gonzalez; C. A. Vaccaro; A. Habr-Gama; Julião G.P. São; F. A. Holman; R. Hompes; W. Lameris; S. H.J. Ketelaers; H. J.T. Rutten; K. Leitner; C. Mazzarisi; L. Malcomson; S. T. O'Dwyer; M. Saunders; A. Maroli; P. Mitchell; S. Murad-Regadas; A. Pairola; Salazar I. Pedraza; Loria F. Sanchez; A. J. Pennings; A. Spinelli; Myint A. Sun

doi:10.1093/bjs/znad051

Watch and wait after neoadjuvant treatment in rectal cancer: Comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & Wait Database (IWWD)

Sofieke J.D. Temmink, Koen C.M.J. Peeters, Renu R. Bahadoer, Elma Meershoek Klein Kranenbarg, Annet G.H. Roodvoets, Jarno Melenhorst, Jacobus W.A. Burger, Albert Wolthuis, Andrew G. Renehan, Nuno L. Figueiredo, Oriol Pares, Anna Martling, Rodrigo O. Perez, Geerard L. Beets, Cornelis J.H. Van De Velde, Per J. Nilsson, M. Aghili, A. Keshvari, M. K. Nouritaromlou, M. AhlbergS. Kordnejad, A. Aleinikov, A. Dulskas, O. Asoǧlu, H. Tokmak, R. G. Barroca, A. F. Caiado, I. A.L. Rosa, S. O. Breukink, M. F. Coraglio, S. Iseas, B. Creaven, D. C. Winter, A. Zaborowski, C. Cunningham, E. Gregory, P. A. Custers, B. M. Geubels, L. Debrun, A. D'Hoore, G. Dimofte, K. Fechner, K. Matzel, L. Fernandez, A. I. Herrando, P. Vieira, W. B. Gaertner, R. D. Madoff, J. P. Gerard, F. Jacquinot, R. Schiappa, S. Gollins, M. Gonzalez, C. A. Vaccaro, A. Habr-Gama, Julião G.P. São, F. A. Holman, R. Hompes, W. Lameris, S. H.J. Ketelaers, H. J.T. Rutten, K. Leitner, C. Mazzarisi, L. Malcomson, S. T. O'Dwyer, M. Saunders, A. Maroli, P. Mitchell, S. Murad-Regadas, A. Pairola, Salazar I. Pedraza, Loria F. Sanchez, A. J. Pennings, A. Spinelli, Myint A. Sun

Surgery

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Background: In rectal cancer, watch and wait for patients with a cCR after neoadjuvant treatment has an established evidence base. However, there is a lack of consensus on the definition and management of a near-cCR. This study aimed to compare outcomes in patients who achieved a cCR at first reassessment versus later reassessment. Methods: This registry study included patients from the International Watch & Wait Database. Patients were categorized as having a cCR at first reassessment or at later reassessment (that is near-cCR at first reassessment) based on MRI and endoscopy. Organ preservation, distant metastasis-free survival, and overall survival rates were calculated. Subgroup analyses were done for near-cCR groups based on the response evaluation according to modality. Results: A total of 1010 patients were identified. At first reassessment, 608 patients had a cCR; 402 had a cCR at later reassessment. Median follow-up was 2.6 years for patients with a cCR at first reassessment and 2.9 years for those with a cCR at later reassessment. The 2-year organ preservation rate was 77.8 (95 per cent c.i. 74.2 to 81.5) and 79.3 (75.1 to 83.7) per cent respectively (P = 0.499). Similarly, no differences were found between groups in distant metastasis-free survival or overall survival rate. Subgroup analyses showed a higher organ preservation rate in the group with a near-cCR categorized exclusively by MRI. Conclusion: Oncological outcomes for patients with a cCR at later reassessment are no worse than those of patients with a cCR at first reassessment.

Original language	English (US)
Pages (from-to)	676-684
Number of pages	9
Journal	British Journal of Surgery
Volume	110
Issue number	6
DOIs	https://doi.org/10.1093/bjs/znad051
State	Published - Jun 1 2023

Bibliographical note

Publisher Copyright:
© 2023 The Author(s). Published by Oxford University Press on behalf of BJS Society Ltd.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1093/bjs/znad051

OpenUrl availability

Full text

Fingerprint

Dive into the research topics of 'Watch and wait after neoadjuvant treatment in rectal cancer: Comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & Wait Database (IWWD)'. Together they form a unique fingerprint.

Cite this

Temmink, S. J. D., Peeters, K. C. M. J., Bahadoer, R. R., Kranenbarg, E. M. K., Roodvoets, A. G. H., Melenhorst, J., Burger, J. W. A., Wolthuis, A., Renehan, A. G., Figueiredo, N. L., Pares, O., Martling, A., Perez, R. O., Beets, G. L., Van De Velde, C. J. H., Nilsson, P. J., Aghili, M., Keshvari, A., Nouritaromlou, M. K., ... Sun, M. A. (2023). Watch and wait after neoadjuvant treatment in rectal cancer: Comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & Wait Database (IWWD). British Journal of Surgery, 110(6), 676-684. https://doi.org/10.1093/bjs/znad051

Watch and wait after neoadjuvant treatment in rectal cancer: Comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & Wait Database (IWWD). / Temmink, Sofieke J.D.; Peeters, Koen C.M.J.; Bahadoer, Renu R. et al.
In: British Journal of Surgery, Vol. 110, No. 6, 01.06.2023, p. 676-684.

Research output: Contribution to journal › Article › peer-review

Temmink, SJD, Peeters, KCMJ, Bahadoer, RR, Kranenbarg, EMK, Roodvoets, AGH, Melenhorst, J, Burger, JWA, Wolthuis, A, Renehan, AG, Figueiredo, NL, Pares, O, Martling, A, Perez, RO, Beets, GL, Van De Velde, CJH, Nilsson, PJ, Aghili, M, Keshvari, A, Nouritaromlou, MK, Ahlberg, M, Kordnejad, S, Aleinikov, A, Dulskas, A, Asoǧlu, O, Tokmak, H, Barroca, RG, Caiado, AF, Rosa, IAL, Breukink, SO, Coraglio, MF, Iseas, S, Creaven, B, Winter, DC, Zaborowski, A, Cunningham, C, Gregory, E, Custers, PA, Geubels, BM, Debrun, L, D'Hoore, A, Dimofte, G, Fechner, K, Matzel, K, Fernandez, L, Herrando, AI, Vieira, P, Gaertner, WB , Madoff, RD, Gerard, JP, Jacquinot, F, Schiappa, R, Gollins, S, Gonzalez, M, Vaccaro, CA, Habr-Gama, A, São, JGP, Holman, FA, Hompes, R, Lameris, W, Ketelaers, SHJ, Rutten, HJT, Leitner, K, Mazzarisi, C, Malcomson, L, O'Dwyer, ST, Saunders, M, Maroli, A, Mitchell, P, Murad-Regadas, S, Pairola, A, Pedraza, SI, Sanchez, LF, Pennings, AJ, Spinelli, A & Sun, MA 2023, 'Watch and wait after neoadjuvant treatment in rectal cancer: Comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & Wait Database (IWWD)', British Journal of Surgery, vol. 110, no. 6, pp. 676-684. https://doi.org/10.1093/bjs/znad051

Temmink SJD, Peeters KCMJ, Bahadoer RR, Kranenbarg EMK, Roodvoets AGH, Melenhorst J et al. Watch and wait after neoadjuvant treatment in rectal cancer: Comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & Wait Database (IWWD). British Journal of Surgery. 2023 Jun 1;110(6):676-684. doi: 10.1093/bjs/znad051

@article{68f6f8f385c84e75875e1bcb7aab26c4,

title = "Watch and wait after neoadjuvant treatment in rectal cancer: Comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & Wait Database (IWWD)",

abstract = "Background: In rectal cancer, watch and wait for patients with a cCR after neoadjuvant treatment has an established evidence base. However, there is a lack of consensus on the definition and management of a near-cCR. This study aimed to compare outcomes in patients who achieved a cCR at first reassessment versus later reassessment. Methods: This registry study included patients from the International Watch & Wait Database. Patients were categorized as having a cCR at first reassessment or at later reassessment (that is near-cCR at first reassessment) based on MRI and endoscopy. Organ preservation, distant metastasis-free survival, and overall survival rates were calculated. Subgroup analyses were done for near-cCR groups based on the response evaluation according to modality. Results: A total of 1010 patients were identified. At first reassessment, 608 patients had a cCR; 402 had a cCR at later reassessment. Median follow-up was 2.6 years for patients with a cCR at first reassessment and 2.9 years for those with a cCR at later reassessment. The 2-year organ preservation rate was 77.8 (95 per cent c.i. 74.2 to 81.5) and 79.3 (75.1 to 83.7) per cent respectively (P = 0.499). Similarly, no differences were found between groups in distant metastasis-free survival or overall survival rate. Subgroup analyses showed a higher organ preservation rate in the group with a near-cCR categorized exclusively by MRI. Conclusion: Oncological outcomes for patients with a cCR at later reassessment are no worse than those of patients with a cCR at first reassessment.",

author = "Temmink, {Sofieke J.D.} and Peeters, {Koen C.M.J.} and Bahadoer, {Renu R.} and Kranenbarg, {Elma Meershoek Klein} and Roodvoets, {Annet G.H.} and Jarno Melenhorst and Burger, {Jacobus W.A.} and Albert Wolthuis and Renehan, {Andrew G.} and Figueiredo, {Nuno L.} and Oriol Pares and Anna Martling and Perez, {Rodrigo O.} and Beets, {Geerard L.} and {Van De Velde}, {Cornelis J.H.} and Nilsson, {Per J.} and M. Aghili and A. Keshvari and Nouritaromlou, {M. K.} and M. Ahlberg and S. Kordnejad and A. Aleinikov and A. Dulskas and O. Asoǧlu and H. Tokmak and Barroca, {R. G.} and Caiado, {A. F.} and Rosa, {I. A.L.} and Breukink, {S. O.} and Coraglio, {M. F.} and S. Iseas and B. Creaven and Winter, {D. C.} and A. Zaborowski and C. Cunningham and E. Gregory and Custers, {P. A.} and Geubels, {B. M.} and L. Debrun and A. D'Hoore and G. Dimofte and K. Fechner and K. Matzel and L. Fernandez and Herrando, {A. I.} and P. Vieira and Gaertner, {W. B.} and Madoff, {R. D.} and Gerard, {J. P.} and F. Jacquinot and R. Schiappa and S. Gollins and M. Gonzalez and Vaccaro, {C. A.} and A. Habr-Gama and S{\~a}o, {Juli{\~a}o G.P.} and Holman, {F. A.} and R. Hompes and W. Lameris and Ketelaers, {S. H.J.} and Rutten, {H. J.T.} and K. Leitner and C. Mazzarisi and L. Malcomson and O'Dwyer, {S. T.} and M. Saunders and A. Maroli and P. Mitchell and S. Murad-Regadas and A. Pairola and Pedraza, {Salazar I.} and Sanchez, {Loria F.} and Pennings, {A. J.} and A. Spinelli and Sun, {Myint A.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by Oxford University Press on behalf of BJS Society Ltd.",

year = "2023",

month = jun,

day = "1",

doi = "10.1093/bjs/znad051",

language = "English (US)",

volume = "110",

pages = "676--684",

journal = "British Journal of Surgery",

issn = "0007-1323",

publisher = "John Wiley and Sons Ltd",

number = "6",

}

TY - JOUR

T1 - Watch and wait after neoadjuvant treatment in rectal cancer

T2 - Comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & Wait Database (IWWD)

AU - Temmink, Sofieke J.D.

AU - Peeters, Koen C.M.J.

AU - Bahadoer, Renu R.

AU - Kranenbarg, Elma Meershoek Klein

AU - Roodvoets, Annet G.H.

AU - Melenhorst, Jarno

AU - Burger, Jacobus W.A.

AU - Wolthuis, Albert

AU - Renehan, Andrew G.

AU - Figueiredo, Nuno L.

AU - Pares, Oriol

AU - Martling, Anna

AU - Perez, Rodrigo O.

AU - Beets, Geerard L.

AU - Van De Velde, Cornelis J.H.

AU - Nilsson, Per J.

AU - Aghili, M.

AU - Keshvari, A.

AU - Nouritaromlou, M. K.

AU - Ahlberg, M.

AU - Kordnejad, S.

AU - Aleinikov, A.

AU - Dulskas, A.

AU - Asoǧlu, O.

AU - Tokmak, H.

AU - Barroca, R. G.

AU - Caiado, A. F.

AU - Rosa, I. A.L.

AU - Breukink, S. O.

AU - Coraglio, M. F.

AU - Iseas, S.

AU - Creaven, B.

AU - Winter, D. C.

AU - Zaborowski, A.

AU - Cunningham, C.

AU - Gregory, E.

AU - Custers, P. A.

AU - Geubels, B. M.

AU - Debrun, L.

AU - D'Hoore, A.

AU - Dimofte, G.

AU - Fechner, K.

AU - Matzel, K.

AU - Fernandez, L.

AU - Herrando, A. I.

AU - Vieira, P.

AU - Gaertner, W. B.

AU - Madoff, R. D.

AU - Gerard, J. P.

AU - Jacquinot, F.

AU - Schiappa, R.

AU - Gollins, S.

AU - Gonzalez, M.

AU - Vaccaro, C. A.

AU - Habr-Gama, A.

AU - São, Julião G.P.

AU - Holman, F. A.

AU - Hompes, R.

AU - Lameris, W.

AU - Ketelaers, S. H.J.

AU - Rutten, H. J.T.

AU - Leitner, K.

AU - Mazzarisi, C.

AU - Malcomson, L.

AU - O'Dwyer, S. T.

AU - Saunders, M.

AU - Maroli, A.

AU - Mitchell, P.

AU - Murad-Regadas, S.

AU - Pairola, A.

AU - Pedraza, Salazar I.

AU - Sanchez, Loria F.

AU - Pennings, A. J.

AU - Spinelli, A.

AU - Sun, Myint A.

PY - 2023/6/1

Y1 - 2023/6/1

N2 - Background: In rectal cancer, watch and wait for patients with a cCR after neoadjuvant treatment has an established evidence base. However, there is a lack of consensus on the definition and management of a near-cCR. This study aimed to compare outcomes in patients who achieved a cCR at first reassessment versus later reassessment. Methods: This registry study included patients from the International Watch & Wait Database. Patients were categorized as having a cCR at first reassessment or at later reassessment (that is near-cCR at first reassessment) based on MRI and endoscopy. Organ preservation, distant metastasis-free survival, and overall survival rates were calculated. Subgroup analyses were done for near-cCR groups based on the response evaluation according to modality. Results: A total of 1010 patients were identified. At first reassessment, 608 patients had a cCR; 402 had a cCR at later reassessment. Median follow-up was 2.6 years for patients with a cCR at first reassessment and 2.9 years for those with a cCR at later reassessment. The 2-year organ preservation rate was 77.8 (95 per cent c.i. 74.2 to 81.5) and 79.3 (75.1 to 83.7) per cent respectively (P = 0.499). Similarly, no differences were found between groups in distant metastasis-free survival or overall survival rate. Subgroup analyses showed a higher organ preservation rate in the group with a near-cCR categorized exclusively by MRI. Conclusion: Oncological outcomes for patients with a cCR at later reassessment are no worse than those of patients with a cCR at first reassessment.

AB - Background: In rectal cancer, watch and wait for patients with a cCR after neoadjuvant treatment has an established evidence base. However, there is a lack of consensus on the definition and management of a near-cCR. This study aimed to compare outcomes in patients who achieved a cCR at first reassessment versus later reassessment. Methods: This registry study included patients from the International Watch & Wait Database. Patients were categorized as having a cCR at first reassessment or at later reassessment (that is near-cCR at first reassessment) based on MRI and endoscopy. Organ preservation, distant metastasis-free survival, and overall survival rates were calculated. Subgroup analyses were done for near-cCR groups based on the response evaluation according to modality. Results: A total of 1010 patients were identified. At first reassessment, 608 patients had a cCR; 402 had a cCR at later reassessment. Median follow-up was 2.6 years for patients with a cCR at first reassessment and 2.9 years for those with a cCR at later reassessment. The 2-year organ preservation rate was 77.8 (95 per cent c.i. 74.2 to 81.5) and 79.3 (75.1 to 83.7) per cent respectively (P = 0.499). Similarly, no differences were found between groups in distant metastasis-free survival or overall survival rate. Subgroup analyses showed a higher organ preservation rate in the group with a near-cCR categorized exclusively by MRI. Conclusion: Oncological outcomes for patients with a cCR at later reassessment are no worse than those of patients with a cCR at first reassessment.

UR - http://www.scopus.com/inward/record.url?scp=85159732702&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85159732702&partnerID=8YFLogxK

U2 - 10.1093/bjs/znad051

DO - 10.1093/bjs/znad051

M3 - Article

C2 - 36972213

AN - SCOPUS:85159732702

SN - 0007-1323

VL - 110

SP - 676

EP - 684

JO - British Journal of Surgery

JF - British Journal of Surgery

IS - 6

ER -

Watch and wait after neoadjuvant treatment in rectal cancer: Comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & Wait Database (IWWD)

Abstract

Bibliographical note

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this