TY - JOUR
T1 - WE‐A‐BRB‐08
T2 - Dosimetric Investigation of Praseodymium‐142 Microspheres for Microsphere Brachytherapy of Nonresectable Hepatic Tumor
AU - Ferreira, M.
AU - Podder, T.
AU - Jung, J.
PY - 2012/6
Y1 - 2012/6
N2 - Purpose: To evaluate the dosimetric parameters of Praseodymium‐142 (1 4 2Pr) glass microspheres and its potential application in microsphere brachytherapy of nonresectable hepatic tumor for faster dose delivery and facilitated quality assurance, while maintaining comparable dose distribution of the currently used radionuclides. Methods: Dose profiles for a 1 4 2Pr point source were obtained using BRAIN‐DOSE dose point kernel code and MCNPX2.6 Monte Carlo simulation. Microspheres containing 142Pr were studied and their dose distributions were compared to the doses of the currently used radionuclide Yittrium‐90 (9 0Y). Dose distributions due to glass microspheres ensembles within different sizes of spherical tumors were simulated. Physical properties, e.g. time to deliver 90% of the total dose for 1 4 2Pr and 9 0Y, were studied. Results: Dose rates from BRAIN‐ DOSE calculation for ‘ 1 4 2Pr and 9 0Y were 4.42 mGy/hr and 5.53 mGy/hr at 0.5 cm away from a 1 μCi source. From MCNPX2.6 the beta dose per decay at the tumor center for 142Pr and 9 0Y were 2.02 × 10−12 Gy and 2.36 × 10−12 Gy, respectively, for a tumor of 2.5 cm radius. For this case, simulation showed that the total dose in the tumor vicinity and therefore to adjacent organs due to the gamma yield was small, e.g. 0.03 Gy at 10 cm from the tumor center for 150 Gy total physical dose. Conclusions: Total dose per decay due to beta emissions were similar for both 1 4 2Pr and 9 0Y. Shorter half‐life is an advantage of ‘ 1 4 2Pr, enabling faster dose delivery. The physical properties of 1 4 2Pr make it suitable for microsphere brachytherapy. Total gamma contribution of 1 4 2Pr was small, therefore may not be clinically relevant. Gamma radiation, however, opens possibilities for quality assurance, biodistribution imaging and dose distribution assessments.
AB - Purpose: To evaluate the dosimetric parameters of Praseodymium‐142 (1 4 2Pr) glass microspheres and its potential application in microsphere brachytherapy of nonresectable hepatic tumor for faster dose delivery and facilitated quality assurance, while maintaining comparable dose distribution of the currently used radionuclides. Methods: Dose profiles for a 1 4 2Pr point source were obtained using BRAIN‐DOSE dose point kernel code and MCNPX2.6 Monte Carlo simulation. Microspheres containing 142Pr were studied and their dose distributions were compared to the doses of the currently used radionuclide Yittrium‐90 (9 0Y). Dose distributions due to glass microspheres ensembles within different sizes of spherical tumors were simulated. Physical properties, e.g. time to deliver 90% of the total dose for 1 4 2Pr and 9 0Y, were studied. Results: Dose rates from BRAIN‐ DOSE calculation for ‘ 1 4 2Pr and 9 0Y were 4.42 mGy/hr and 5.53 mGy/hr at 0.5 cm away from a 1 μCi source. From MCNPX2.6 the beta dose per decay at the tumor center for 142Pr and 9 0Y were 2.02 × 10−12 Gy and 2.36 × 10−12 Gy, respectively, for a tumor of 2.5 cm radius. For this case, simulation showed that the total dose in the tumor vicinity and therefore to adjacent organs due to the gamma yield was small, e.g. 0.03 Gy at 10 cm from the tumor center for 150 Gy total physical dose. Conclusions: Total dose per decay due to beta emissions were similar for both 1 4 2Pr and 9 0Y. Shorter half‐life is an advantage of ‘ 1 4 2Pr, enabling faster dose delivery. The physical properties of 1 4 2Pr make it suitable for microsphere brachytherapy. Total gamma contribution of 1 4 2Pr was small, therefore may not be clinically relevant. Gamma radiation, however, opens possibilities for quality assurance, biodistribution imaging and dose distribution assessments.
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U2 - 10.1118/1.4736049
DO - 10.1118/1.4736049
M3 - Article
AN - SCOPUS:85024818069
SN - 0094-2405
VL - 39
SP - 3932
EP - 3933
JO - Medical Physics
JF - Medical Physics
IS - 6
ER -