Whole Blood Serotonin Levels and Platelet 5-HT                         2A                          Binding in Autism Spectrum Disorder

Elizabeth Aaron; Alicia Montgomery; Xinguo Ren; Stephen Guter; George Anderson; Ana M.D. Carneiro; Suma Jacob; Matthew Mosconi; Ghanshyam N. Pandey; Edwin Cook; Jeremy Veenstra-VanderWeele

doi:10.1007/s10803-019-03989-z

Whole Blood Serotonin Levels and Platelet 5-HT _2A Binding in Autism Spectrum Disorder

Elizabeth Aaron, Alicia Montgomery, Xinguo Ren, Stephen Guter, George Anderson, Ana M.D. Carneiro, Suma Jacob, Matthew Mosconi, Ghanshyam N. Pandey, Edwin Cook, Jeremy Veenstra-VanderWeele

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Elevated whole blood serotonin (WB5-HT) is a well-replicated biomarker in autism spectrum disorder (ASD). Decreased platelet serotonin receptor 5-HT _2A binding has been reported in ASD. WB5-HT levels and platelet 5-HT _2A specific binding were obtained from 110 individuals with ASD and 18 controls. Individuals with ASD had significantly higher WB5-HT levels than controls. There was no difference in the platelet 5-HT _2A specific binding between groups. Multiple regression analyses revealed that platelet 5-HT _2A binding significantly predicted WB5-HT in the control sample but not in the ASD sample. These results indicate that the relationship between WB5-HT and platelet 5-HT _2A binding differs depending on ASD diagnosis, suggesting differences in platelet 5-HT system regulation in ASD.

Original language	English (US)
Journal	Journal of Autism and Developmental Disorders
DOIs	https://doi.org/10.1007/s10803-019-03989-z
State	Published - Jan 1 2019

Bibliographical note

Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

Autism spectrum disorder
Biomarker
Hyperserotonemia
Receptor
Serotonin

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10.1007/s10803-019-03989-z

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Cite this

Aaron, E., Montgomery, A., Ren, X., Guter, S., Anderson, G., Carneiro, A. M. D., Jacob, S., Mosconi, M., Pandey, G. N., Cook, E., & Veenstra-VanderWeele, J. (2019). Whole Blood Serotonin Levels and Platelet 5-HT _2A Binding in Autism Spectrum Disorder Journal of Autism and Developmental Disorders. https://doi.org/10.1007/s10803-019-03989-z

Whole Blood Serotonin Levels and Platelet 5-HT _2A Binding in Autism Spectrum Disorder . / Aaron, Elizabeth; Montgomery, Alicia; Ren, Xinguo et al.
In: Journal of Autism and Developmental Disorders, 01.01.2019.

Research output: Contribution to journal › Article › peer-review

Aaron, E, Montgomery, A, Ren, X, Guter, S, Anderson, G, Carneiro, AMD, Jacob, S, Mosconi, M, Pandey, GN, Cook, E & Veenstra-VanderWeele, J 2019, ' Whole Blood Serotonin Levels and Platelet 5-HT _2A Binding in Autism Spectrum Disorder ', Journal of Autism and Developmental Disorders. https://doi.org/10.1007/s10803-019-03989-z

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