World Health Organization Group I Pulmonary Hypertension: Epidemiology and Pathophysiology

Kurt W. Prins; Thenappan Thenappan

doi:10.1016/j.ccl.2016.04.001

World Health Organization Group I Pulmonary Hypertension: Epidemiology and Pathophysiology

Kurt W. Prins, Thenappan Thenappan

Medicine - Cardiology Division

Research output: Contribution to journal › Review article › peer-review

102 Scopus citations

Abstract

Pulmonary arterial hypertension (PAH) is a debilitating disease characterized by pathologic remodeling of the resistance pulmonary arteries, ultimately leading to right ventricular (RV) failure and death. In this article we discuss the definition of PAH, the initial epidemiology based on the National Institutes of Health Registry, and the updated epidemiology gleaned from contemporary registries, pathogenesis of pulmonary vascular dysfunction and proliferation, and RV failure in PAH.

Original language	English (US)
Pages (from-to)	363-374
Number of pages	12
Journal	Cardiology Clinics
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/j.ccl.2016.04.001
State	Published - Aug 1 2016

Bibliographical note

Funding Information:
Funding: T. Thenappan was funded by AHA Scientist Development Grant 15SDG25560048 and K.W. Prins was funded by National Institutes of Health F32 grant HL129554 .

Publisher Copyright:
© 2016 Elsevier Inc.

Keywords

Epidemiology
Pathophysiology
Pulmonary arterial hypertension
Pulmonary vasculature
Right ventricle

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1016/j.ccl.2016.04.001

http://europepmc.org/articles/pmc4959804

OpenUrl availability

Full text

Cite this

@article{4818d498bdc341d8a11c00bf58daeb41,

title = "World Health Organization Group I Pulmonary Hypertension: Epidemiology and Pathophysiology",

abstract = "Pulmonary arterial hypertension (PAH) is a debilitating disease characterized by pathologic remodeling of the resistance pulmonary arteries, ultimately leading to right ventricular (RV) failure and death. In this article we discuss the definition of PAH, the initial epidemiology based on the National Institutes of Health Registry, and the updated epidemiology gleaned from contemporary registries, pathogenesis of pulmonary vascular dysfunction and proliferation, and RV failure in PAH.",

keywords = "Epidemiology, Pathophysiology, Pulmonary arterial hypertension, Pulmonary vasculature, Right ventricle",

author = "Prins, {Kurt W.} and Thenappan Thenappan",

note = "Funding Information: Funding: T. Thenappan was funded by AHA Scientist Development Grant 15SDG25560048 and K.W. Prins was funded by National Institutes of Health F32 grant HL129554 . Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

month = aug,

day = "1",

doi = "10.1016/j.ccl.2016.04.001",

language = "English (US)",

volume = "34",

pages = "363--374",

journal = "Cardiology Clinics",

issn = "0733-8651",

publisher = "W.B. Saunders Ltd",

number = "3",

}

TY - JOUR

T1 - World Health Organization Group I Pulmonary Hypertension

T2 - Epidemiology and Pathophysiology

AU - Prins, Kurt W.

AU - Thenappan, Thenappan

N1 - Funding Information: Funding: T. Thenappan was funded by AHA Scientist Development Grant 15SDG25560048 and K.W. Prins was funded by National Institutes of Health F32 grant HL129554 . Publisher Copyright: © 2016 Elsevier Inc.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Pulmonary arterial hypertension (PAH) is a debilitating disease characterized by pathologic remodeling of the resistance pulmonary arteries, ultimately leading to right ventricular (RV) failure and death. In this article we discuss the definition of PAH, the initial epidemiology based on the National Institutes of Health Registry, and the updated epidemiology gleaned from contemporary registries, pathogenesis of pulmonary vascular dysfunction and proliferation, and RV failure in PAH.

AB - Pulmonary arterial hypertension (PAH) is a debilitating disease characterized by pathologic remodeling of the resistance pulmonary arteries, ultimately leading to right ventricular (RV) failure and death. In this article we discuss the definition of PAH, the initial epidemiology based on the National Institutes of Health Registry, and the updated epidemiology gleaned from contemporary registries, pathogenesis of pulmonary vascular dysfunction and proliferation, and RV failure in PAH.

KW - Epidemiology

KW - Pathophysiology

KW - Pulmonary arterial hypertension

KW - Pulmonary vasculature

KW - Right ventricle

UR - http://www.scopus.com/inward/record.url?scp=84989947749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84989947749&partnerID=8YFLogxK

U2 - 10.1016/j.ccl.2016.04.001

DO - 10.1016/j.ccl.2016.04.001

M3 - Review article

C2 - 27443134

AN - SCOPUS:84989947749

SN - 0733-8651

VL - 34

SP - 363

EP - 374

JO - Cardiology Clinics

JF - Cardiology Clinics

IS - 3

ER -

World Health Organization Group I Pulmonary Hypertension: Epidemiology and Pathophysiology

Abstract

Bibliographical note

Keywords

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this