ZAP-70: an essential kinase in T-cell signaling.

Haopeng Wang; Theresa A. Kadlecek; Byron B. Au-Yeung; Hanna E.Sjölin Goodfellow; Lih Yun Hsu; Tanya S. Freedman; Arthur Weiss

doi:10.1101/cshperspect.a002279

ZAP-70: an essential kinase in T-cell signaling.

Haopeng Wang, Theresa A. Kadlecek, Byron B. Au-Yeung, Hanna E.Sjölin Goodfellow, Lih Yun Hsu, Tanya S. Freedman, Arthur Weiss

Pharmacology

Research output: Contribution to journal › Review article › peer-review

269 Scopus citations

Abstract

ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in which ZAP-70 function can be interrupted by a small chemical inhibitor.

Original language	English (US)
Pages (from-to)	a002279
Journal	Cold Spring Harbor Perspectives in Biology
Volume	2
Issue number	5
DOIs	https://doi.org/10.1101/cshperspect.a002279
State	Published - May 1 2010

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title = "ZAP-70: an essential kinase in T-cell signaling.",

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AU - Wang, Haopeng

AU - Kadlecek, Theresa A.

AU - Au-Yeung, Byron B.

AU - Goodfellow, Hanna E.Sjölin

AU - Hsu, Lih Yun

AU - Freedman, Tanya S.

AU - Weiss, Arthur

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AB - ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in which ZAP-70 function can be interrupted by a small chemical inhibitor.

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ZAP-70: an essential kinase in T-cell signaling.

Abstract

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