Evidence for coordinated functional activity within the extended amygdala of non-human and human primates

Jonathan A. Oler; Rasmus M. Birn; Rémi Patriat; Andrew S. Fox; Steven E. Shelton; Cory A. Burghy; Diane E. Stodola; Marilyn J. Essex; Richard J. Davidson; Ned H. Kalin

doi:10.1016/j.neuroimage.2012.03.045

Evidence for coordinated functional activity within the extended amygdala of non-human and human primates

Jonathan A. Oler, Rasmus M. Birn, Rémi Patriat, Andrew S. Fox, Steven E. Shelton, Cory A. Burghy, Diane E. Stodola, Marilyn J. Essex, Richard J. Davidson, Ned H. Kalin

Radiology

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Abstract

Neuroanatomists posit that the central nucleus of the amygdala (Ce) and bed nucleus of the stria terminalis (BST) comprise two major nodes of a macrostructural forebrain entity termed the extended amygdala. The extended amygdala is thought to play a critical role in adaptive motivational behavior and is implicated in the pathophysiology of maladaptive fear and anxiety. Resting functional connectivity of the Ce was examined in 107 young anesthetized rhesus monkeys and 105 young humans using standard resting-state functional magnetic resonance imaging (fMRI) methods to assess temporal correlations across the brain. The data expand the neuroanatomical concept of the extended amygdala by finding, in both species, highly significant functional coupling between the Ce and the BST. These results support the use of in vivo functional imaging methods in nonhuman and human primates to probe the functional anatomy of major brain networks such as the extended amygdala.

Original language	English (US)
Pages (from-to)	1059-1066
Number of pages	8
Journal	NeuroImage
Volume	61
Issue number	4
DOIs	https://doi.org/10.1016/j.neuroimage.2012.03.045
State	Published - Jul 16 2012

Bibliographical note

Funding Information:
This work was supported by the HealthEmotions Research Institute and the National Institutes of Mental Health : R01-MH046729 (to N.H.K.), R01-MH081884 (to N.H.K.), P50-MH084051 (to R.J.D, M.J.E. N.H.K.) and P30-HD03352 . We thank the staff of the Harlow Center for Biological Psychology, HealthEmotions Research Institute, Waisman Laboratory for Brain Imaging and Behavior, Wisconsin National Primate Center, J. M. Armstrong, B. Christian, M. Jesson, E. Larson, K. Myer, M. Riedel, A. J. Shackman, J. Storey and H. Van Valkenberg.

Keywords

Bed nucleus of the stria terminalis
Central nucleus
Connectivity
Human
Resting-state fMRI
Rhesus macaque

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title = "Evidence for coordinated functional activity within the extended amygdala of non-human and human primates",

abstract = "Neuroanatomists posit that the central nucleus of the amygdala (Ce) and bed nucleus of the stria terminalis (BST) comprise two major nodes of a macrostructural forebrain entity termed the extended amygdala. The extended amygdala is thought to play a critical role in adaptive motivational behavior and is implicated in the pathophysiology of maladaptive fear and anxiety. Resting functional connectivity of the Ce was examined in 107 young anesthetized rhesus monkeys and 105 young humans using standard resting-state functional magnetic resonance imaging (fMRI) methods to assess temporal correlations across the brain. The data expand the neuroanatomical concept of the extended amygdala by finding, in both species, highly significant functional coupling between the Ce and the BST. These results support the use of in vivo functional imaging methods in nonhuman and human primates to probe the functional anatomy of major brain networks such as the extended amygdala.",

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note = "Funding Information: This work was supported by the HealthEmotions Research Institute and the National Institutes of Mental Health : R01-MH046729 (to N.H.K.), R01-MH081884 (to N.H.K.), P50-MH084051 (to R.J.D, M.J.E. N.H.K.) and P30-HD03352 . We thank the staff of the Harlow Center for Biological Psychology, HealthEmotions Research Institute, Waisman Laboratory for Brain Imaging and Behavior, Wisconsin National Primate Center, J. M. Armstrong, B. Christian, M. Jesson, E. Larson, K. Myer, M. Riedel, A. J. Shackman, J. Storey and H. Van Valkenberg.",

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AU - Oler, Jonathan A.

AU - Birn, Rasmus M.

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AU - Shelton, Steven E.

AU - Burghy, Cory A.

AU - Stodola, Diane E.

AU - Essex, Marilyn J.

AU - Davidson, Richard J.

AU - Kalin, Ned H.

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Evidence for coordinated functional activity within the extended amygdala of non-human and human primates

Abstract

Bibliographical note

Keywords

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